The tumour suppressor breast cancer type 1 susceptibility protein (BRCA1) promotes DNA
double-strand break (DSB) repair by homologous recombination and protects DNA …

Globally, breast cancer is both the most commonly occurring cancer and the commonest
cause of cancer death among women. Available data suggest that incidence and mortality in …

The cellular response to external stress signals and DNA damage depends on the activity of
ubiquitin ligases (E3s), which regulate numerous cellular processes, including homeostasis …

Genome instability is a hallmark of cancer, and DNA replication is the most vulnerable
cellular process that can lead to it. Any condition leading to high levels of DNA damage will …

Tumour-initiating cells (TICs) are responsible for metastatic dissemination and clinical
relapse in a variety of cancers,. Analogies between TICs and normal tissue stem cells have …

Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …

High-grade serous ovarian carcinoma presents significant clinical and therapeutic
challenges. Although the traditional model of carcinogenesis has focused on the ovary as a …

Tumors exhibit altered metabolism compared to normal tissues. Many cancers upregulate
expression of serine synthesis pathway enzymes, and some tumors exhibit copy-number …

The pyruvate kinase M2 isoform (PKM2) is expressed in cancer and plays a role in
regulating anabolic metabolism. To determine whether PKM2 is required for tumor formation …

Defective DNA repair by homologous recombination (HR) is thought to be a major
contributor to tumorigenesis in individuals carrying Brca1 mutations. Here, we show that …