[HTML][HTML] mRNA-based therapeutics: powerful and versatile tools to combat diseases

S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …

[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

[HTML][HTML] Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

BS Sheena, L Hiebert, H Han, H Ippolito… - The lancet …, 2022 - thelancet.com
Background Combating viral hepatitis is part of the UN Sustainable Development Goals
(SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector …

Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation

A Mahajan, CN Spracklen, W Zhang, MCY Ng… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …

[HTML][HTML] Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling …

D Adeloye, P Song, Y Zhu, H Campbell… - The Lancet …, 2022 - thelancet.com
Background Chronic obstructive pulmonary disease (COPD) is an increasingly important
cause of morbidity, disability, and mortality worldwide. We aimed to estimate global …

A global view of the interplay between non-alcoholic fatty liver disease and diabetes

N Stefan, K Cusi - The lancet Diabetes & endocrinology, 2022 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, much like other non-
communicable diseases (NCDs), such as cancer, obesity, diabetes, and cardiovascular …

Global prevalence of depression and elevated depressive symptoms among adolescents: A systematic review and meta‐analysis

S Shorey, ED Ng, CHJ Wong - British Journal of Clinical …, 2022 - Wiley Online Library
Objective Adolescence is a formative and turbulent phase where physiological,
psychosocial, and cognitive changes leave adolescents vulnerable to psychological …

Head and neck cancer

MD Mody, JW Rocco, SS Yom, RI Haddad, NF Saba - The Lancet, 2021 - thelancet.com
Head and neck cancer is the seventh most common type of cancer worldwide and comprise
of a diverse group of tumours affecting the upper aerodigestive tract. Although many different …

The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030

B Vogel, M Acevedo, Y Appelman, CNB Merz… - The Lancet, 2021 - thelancet.com
Cardiovascular disease is the leading cause of death in women. Decades of grassroots
campaigns have helped to raise awareness about the impact of cardiovascular disease in …

Preoperative chemotherapy for operable colon cancer: mature results of an international randomized controlled trial

D Morton, M Seymour, L Magill, K Handley… - Journal of clinical …, 2023 - ascopubs.org
PURPOSE Neoadjuvant chemotherapy (NAC) has potential advantages over standard
postoperative chemotherapy for locally advanced colon cancer but requires formal …