[HTML][HTML] mRNA-based therapeutics: powerful and versatile tools to combat diseases
S Qin, X Tang, Y Chen, K Chen, N Fan… - Signal transduction and …, 2022 - nature.com
The therapeutic use of messenger RNA (mRNA) has fueled great hope to combat a wide
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
range of incurable diseases. Recent rapid advances in biotechnology and molecular …
[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …
more than 500 million population worldwide. OA was believed to be caused by the wearing …
[HTML][HTML] Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
BS Sheena, L Hiebert, H Han, H Ippolito… - The lancet …, 2022 - thelancet.com
Background Combating viral hepatitis is part of the UN Sustainable Development Goals
(SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector …
(SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector …
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
A Mahajan, CN Spracklen, W Zhang, MCY Ng… - Nature …, 2022 - nature.com
We assembled an ancestrally diverse collection of genome-wide association studies
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
(GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls …
[HTML][HTML] Global, regional, and national prevalence of, and risk factors for, chronic obstructive pulmonary disease (COPD) in 2019: a systematic review and modelling …
Background Chronic obstructive pulmonary disease (COPD) is an increasingly important
cause of morbidity, disability, and mortality worldwide. We aimed to estimate global …
cause of morbidity, disability, and mortality worldwide. We aimed to estimate global …
A global view of the interplay between non-alcoholic fatty liver disease and diabetes
N Stefan, K Cusi - The lancet Diabetes & endocrinology, 2022 - thelancet.com
Non-alcoholic fatty liver disease (NAFLD) has become an epidemic, much like other non-
communicable diseases (NCDs), such as cancer, obesity, diabetes, and cardiovascular …
communicable diseases (NCDs), such as cancer, obesity, diabetes, and cardiovascular …
Global prevalence of depression and elevated depressive symptoms among adolescents: A systematic review and meta‐analysis
S Shorey, ED Ng, CHJ Wong - British Journal of Clinical …, 2022 - Wiley Online Library
Objective Adolescence is a formative and turbulent phase where physiological,
psychosocial, and cognitive changes leave adolescents vulnerable to psychological …
psychosocial, and cognitive changes leave adolescents vulnerable to psychological …
Head and neck cancer
Head and neck cancer is the seventh most common type of cancer worldwide and comprise
of a diverse group of tumours affecting the upper aerodigestive tract. Although many different …
of a diverse group of tumours affecting the upper aerodigestive tract. Although many different …
The Lancet women and cardiovascular disease Commission: reducing the global burden by 2030
Cardiovascular disease is the leading cause of death in women. Decades of grassroots
campaigns have helped to raise awareness about the impact of cardiovascular disease in …
campaigns have helped to raise awareness about the impact of cardiovascular disease in …
Preoperative chemotherapy for operable colon cancer: mature results of an international randomized controlled trial
PURPOSE Neoadjuvant chemotherapy (NAC) has potential advantages over standard
postoperative chemotherapy for locally advanced colon cancer but requires formal …
postoperative chemotherapy for locally advanced colon cancer but requires formal …