Guidelines for the treatment of chronic spontaneous urticaria (CSU) recommend the use of
the IgE-targeted biologic omalizumab in patients with antihistamine-refractory disease. The …

Importance Omalizumab is indicated for the management of chronic idiopathic urticaria
(CIU)(also known as chronic spontaneous urticaria) in adolescents and adults with …

Background Autoimmune chronic spontaneous urticaria (aiCSU) is an important subtype of
chronic spontaneous urticaria (CSU) in which functional IgG autoantibodies to IgE or its high …

Background Omalizumab is an effective and well‐tolerated treatment for chronic
spontaneous urticaria (CSU). Markers and predictors of response are largely unknown, but …

Background Chronic spontaneous urticaria (CSU) is defined as spontaneous occurrence of
wheals and/or angioedema for≥ 6 weeks. Omalizumab is a monoclonal anti‐IgE antibody …

For Peer Review Page 1 For Peer Review Total IgE levels are linked to the response of chronic
spontaneous urticaria patients to omalizumab Journal: Allergy Manuscript ID ALL-2018-00264 …

Although the efficacy of omalizumab has been clearly demonstrated in the treatment of
chronic spontaneous urticaria (CSU), its mechanism of action, which results in improvement …

Urticaria has been known as a disease since antiquity. However, in the last decades an
increasing understanding of the mechanisms involved in its pathogenesis has shown the …

Chronic spontaneous urticaria (CSU) pathogenesis shows a complex and still unclear
interplay between immunoglobulin (Ig) G-and IgE-mediated autoimmunity, leading to mast …

Chronic urticaria (CU) is defined as the appearance of pruritic migratory wheals,
angioedema, or both on most days of the week for more than 6 weeks. First line therapies for …