Experimental research has recognized the importance of cardiac fibroblast and
myofibroblast cells in heart repair and function. In a normal healthy heart, the cardiac …

Fibrosis, a common process of chronic inflammatory diseases, is defined as a repair
response disorder when organs undergo continuous damage, ultimately leading to scar …

The inappropriate deposition of extracellular matrix within the heart (termed cardiac fibrosis)
is associated with nearly all types of heart disease, including ischemic, hypertensive …

Cardiovascular and metabolic diseases such as hypertension, type 2 diabetes, and obesity
develop long-term fibrotic processes in the heart, promoting pathological cardiac …

Myofibroblasts escape apoptosis and proliferate abnormally under pathological conditions,
especially fibrosis; they synthesize and secrete a large amount of extracellular matrix (ECM) …

Myocardial fibrosis (MF) is a reactive remodeling process in response to myocardial injury. It
is mainly manifested by the proliferation of cardiac muscle fibroblasts and secreting …

Cardiac fibrosis is a process characterized by extracellular matrix accumulation leading to
myocardial dysfunction. Angiotensin II (Ang II) has been shown to play an important role in …

Fibrosis is a significant global health problem associated with many inflammatory and
degenerative diseases affecting multiple organs, individually or simultaneously. Fibrosis …

Abstract Background Systemic sclerosis (SSc) is a connective tissue disorder characterized
by the development of fibrosis in the skin and internal organs. Increasing evidence suggests …

A mounting body of evidence has suggested that long noncoding RNAs (lncRNAs) play
critical roles in human diseases by acting as competing endogenous RNAs (ceRNAs) …