Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …

Drug discovery and development is a high-risk, expensive endeavor and it commonly takes
about 10− 15 years to obtain marketing approval from project inception. 1 Research efforts …

New mass spectrometry imaging (MSI) techniques are gaining importance in various stages
of the drug discovery and development chain as well as in more fundamental studies of drug …

Mass spectrometry imaging (MSI) is a powerful analytical technique that enables label-free
spatial localization and identification of molecules in complex samples. 1− 4 MSI …

Desorption electrospray ionization mass spectrometry imaging (DESI‐MSI) is one of the
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …

Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

A new tissue sample embedding and processing method is presented that provides
downstream compatibility with numerous different histological, molecular biology, and …

In the past 15 years, ambient ionization techniques have witnessed a significant incursion
into the field of mass spectrometry imaging, demonstrating their ability to provide …

During the past decade, mass spectrometry imaging (MSI) has become a robust and
versatile methodology to support modern pharmaceutical research and development. The …

A new, more robust sprayer for desorption electrospray ionization (DESI) mass spectrometry
imaging is presented. The main source of variability in DESI is thought to be the uncontrolled …