Basic and therapeutic aspects of angiogenesis updated

G Eelen, L Treps, X Li, P Carmeliet - Circulation research, 2020 - Am Heart Assoc
All organisms growing beyond the oxygen diffusion limit critically depend on a functional
vasculature for survival. Yet blood vessels are far more than passive, uniform conduits for …

Varicocele-mediated male infertility: from the perspective of testicular immunity and inflammation

Y Fang, Y Su, J Xu, Z Hu, K Zhao, C Liu… - Frontiers in …, 2021 - frontiersin.org
Background Varicocele (VC) is present in 35-40% of men with infertility. However, current
surgical and antioxidant treatments are not completely effective. In addition to oxidative …

Transfer learning enables predictions in network biology

CV Theodoris, L Xiao, A Chopra, MD Chaffin… - Nature, 2023 - nature.com
Mapping gene networks requires large amounts of transcriptomic data to learn the
connections between genes, which impedes discoveries in settings with limited data …

A single–cell type transcriptomics map of human tissues

M Karlsson, C Zhang, L Méar, W Zhong, A Digre… - Science …, 2021 - science.org
Advances in molecular profiling have opened up the possibility to map the expression of
genes in cells, tissues, and organs in the human body. Here, we combined single-cell …

The protein expression profile of ACE2 in human tissues

F Hikmet, L Méar, Å Edvinsson, P Micke… - Molecular systems …, 2020 - embopress.org
The novel SARS‐coronavirus 2 (SARS‐CoV‐2) poses a global challenge on healthcare and
society. For understanding the susceptibility for SARS‐CoV‐2 infection, the cell type‐specific …

[HTML][HTML] SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

W Sungnak, N Huang, C Bécavin, M Berg, R Queen… - Nature medicine, 2020 - nature.com
We investigated SARS-CoV-2 potential tropism by surveying expression of viral entry-
associated genes in single-cell RNA-sequencing data from multiple tissues from healthy …

Construction of a human cell landscape at single-cell level

X Han, Z Zhou, L Fei, H Sun, R Wang, Y Chen, H Chen… - Nature, 2020 - nature.com
Single-cell analysis is a valuable tool for dissecting cellular heterogeneity in complex
systems. However, a comprehensive single-cell atlas has not been achieved for humans …

[HTML][HTML] No evidence of severe acute respiratory syndrome–coronavirus 2 in semen of males recovering from coronavirus disease 2019

F Pan, X Xiao, J Guo, Y Song, H Li, DP Patel… - Fertility and sterility, 2020 - Elsevier
Objective To describe detection of severe acute respiratory syndrome (SARS)–coronavirus 2
(CoV-2) in seminal fluid of patients recovering from coronavirus disease 2019 (COVID-19) …

RNA velocity unraveled

G Gorin, M Fang, T Chari, L Pachter - PLOS Computational …, 2022 - journals.plos.org
We perform a thorough analysis of RNA velocity methods, with a view towards
understanding the suitability of the various assumptions underlying popular …

[HTML][HTML] Coronavirus disease-19 and fertility: viral host entry protein expression in male and female reproductive tissues

KE Stanley, E Thomas, M Leaver, D Wells - Fertility and sterility, 2020 - Elsevier
Objective To identify cell types in the male and female reproductive systems at risk for SARS-
CoV-2 infection because of the expression of host genes and proteins used by the virus for …