Substantial research over the past two decades has established that extracellular matrix
(ECM) elasticity, or stiffness, affects fundamental cellular processes, including spreading …

The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Lipids are essential metabolites, which function as energy sources, structural components
and signalling mediators. Most cells are able to convert carbohydrates into fatty acids, which …

Hepatic, pancreatic, and biliary (HPB) organoids are powerful tools for studying
development, disease, and regeneration. As organoid research expands, the need for clear …

Non-Alcoholic Steatohepatitis (NASH) is the progressive form of Non-Alcoholic Fatty Liver
Disease (NAFLD), the main cause of chronic liver complications. The development of NASH …

Metabolic diseases, including obesity, diabetes mellitus and cardiovascular disease, are a
major threat to health in the modern world, but efforts to understand the underlying …

Nonalcoholic steatohepatitis (NASH) is a liver disease associated with significant morbidity.
Kupffer cells (KCs) produce endogenous miR-690 and, via exosome secretion, shuttle this …

The gut microbiota has been implicated in cancer and shown to modulate anticancer drug
efficacy. Altered gut microbiota is associated with resistance to chemo drugs or immune …

Animal models are crucial for improving our understanding of human pathogenesis,
enabling researchers to identify therapeutic targets and test novel drugs. In the current …

With recent progress in modeling liver organogenesis and regeneration, the lack of
vasculature is becoming the bottleneck in progressing our ability to model human hepatic …