Lipopolysaccharide recognition in the crossroads of TLR4 and caspase-4/11 mediated inflammatory pathways
A Zamyatina, H Heine - Frontiers in Immunology, 2020 - frontiersin.org
The innate immune response to lipopolysaccharide is essential for host defense against
Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is …
Gram-negative bacteria. In response to bacterial infection, the TLR4/MD-2 complex that is …
[HTML][HTML] The interleukin-1 family: back to the future
C Garlanda, CA Dinarello, A Mantovani - Immunity, 2013 - cell.com
Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …
Innate immune recognition
CA Janeway Jr, R Medzhitov - Annual review of immunology, 2002 - annualreviews.org
The innate immune system is a universal and ancient form of host defense against infection.
Innate immune recognition relies on a limited number of germline-encoded receptors. These …
Innate immune recognition relies on a limited number of germline-encoded receptors. These …
Immunobiology of dendritic cells
J Banchereau, F Briere, C Caux… - Annual review of …, 2000 - annualreviews.org
Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary
immune responses. DCs capture and transfer information from the outside world to the cells …
immune responses. DCs capture and transfer information from the outside world to the cells …
Toll-like receptors
K Takeda, T Kaisho, S Akira - Annual review of immunology, 2003 - annualreviews.org
The innate immune system in drosophila and mammals senses the invasion of
microorganisms using the family of Toll receptors, stimulation of which initiates a range of …
microorganisms using the family of Toll receptors, stimulation of which initiates a range of …
Toll-like receptors and innate immunity
S Akira - Advances in immunology, 2001 - Elsevier
Immunity in higher organisms can be broadly categorized into adaptive immunity and innate
immunity. Adaptive immunity is mediated by clonally distributed T and B lymphocytes which …
immunity. Adaptive immunity is mediated by clonally distributed T and B lymphocytes which …
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
LAJ O'Neill, AG Bowie - Nature Reviews Immunology, 2007 - nature.com
Signalling by Toll-like receptors (TLRs) involves five adaptor proteins known as MyD88,
MAL, TRIF, TRAM and SARM. Recent insights have revealed additional functions for MyD88 …
MAL, TRIF, TRAM and SARM. Recent insights have revealed additional functions for MyD88 …
Toll-like receptors in the induction of the innate immune response
A Aderem, RJ Ulevitch - Nature, 2000 - nature.com
The innate immune response is the first line of defence against infectious disease. The
principal challenge for the host is to detect the pathogen and mount a rapid defensive …
principal challenge for the host is to detect the pathogen and mount a rapid defensive …
Therapeutic potential of Toll-like receptor 9 activation
AM Krieg - Nature reviews Drug discovery, 2006 - nature.com
In the decade since the discovery that mouse B cells respond to certain unmethylated CpG
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …
dinucleotides in bacterial DNA, a specific receptor for these'CpG motifs' has been identified …
[HTML][HTML] Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
O Takeuchi, K Hoshino, T Kawai, H Sanjo, H Takada… - Immunity, 1999 - cell.com
Abstract Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various
bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo …
bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo …