Rat models of human diseases and related phenotypes: a systematic inventory of the causative genes
C Szpirer - Journal of biomedical science, 2020 - Springer
The laboratory rat has been used for a long time as the model of choice in several
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …
biomedical disciplines. Numerous inbred strains have been isolated, displaying a wide …
Contribution of cerebral microvascular mechanisms to age-related cognitive impairment and dementia
X Fang, RF Crumpler, KN Thomas… - Physiology …, 2022 - akjournals.com
Cognitive impairment and dementia are significant health burdens worldwide. Aging,
hypertension, and diabetes are the primary risk factors for Alzheimer's disease and …
hypertension, and diabetes are the primary risk factors for Alzheimer's disease and …
Aging exacerbates impairments of cerebral blood flow autoregulation and cognition in diabetic rats
S Wang, W Lv, H Zhang, Y Liu, L Li, JR Jefferson… - Geroscience, 2020 - Springer
Diabetes mellitus (DM) is a leading risk factor for aging-related dementia; however, the
underlying mechanisms are not well understood. The present study, utilizing a non-obese …
underlying mechanisms are not well understood. The present study, utilizing a non-obese …
Luseogliflozin, a sodium-glucose cotransporter-2 inhibitor, reverses cerebrovascular dysfunction and cognitive impairments in 18-mo-old diabetic animals
Diabetes mellitus (DM) is a leading risk factor for age-related dementia, but the mechanisms
involved are not well understood. We previously discovered that hyperglycemia induced …
involved are not well understood. We previously discovered that hyperglycemia induced …
Longitudinal characterization of cerebral hemodynamics in the TgF344-AD rat model of Alzheimer's disease
Alzheimer's disease (AD) is a global healthcare crisis. The TgF344-AD rat is an AD model
exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed …
exhibiting age-dependent AD pathological hallmarks. We confirmed that AD rats developed …
Renoprotective effects of empagliflozin in type 1 and type 2 models of diabetic nephropathy superimposed with hypertension
Diabetes, hypertension, and aging are major contributors to cardiovascular and chronic
kidney disease (CKD). Sodium/glucose cotransporter 2 (SGLT2) inhibitors have become a …
kidney disease (CKD). Sodium/glucose cotransporter 2 (SGLT2) inhibitors have become a …
20-HETE-promoted cerebral blood flow autoregulation is associated with enhanced pericyte contractility
We previously reported that deficiency in 20-HETE or CYP4A impaired the myogenic
response and autoregulation of cerebral blood flow (CBF) in rats. The present study …
response and autoregulation of cerebral blood flow (CBF) in rats. The present study …
Genetic susceptibility of hypertension‐induced kidney disease
Hypertension is the second leading cause of end‐stage renal disease (ESRD) after diabetes
mellitus. The significant differences in the incidence of hypertensive ESRD between different …
mellitus. The significant differences in the incidence of hypertensive ESRD between different …
mRatBN7. 2: familiar and unfamiliar features of a new rat genome reference assembly
Rat genomic tools have been slower to emerge than for those of humans and mice and have
remained less thorough and comprehensive. The arrival of a new and improved rat …
remained less thorough and comprehensive. The arrival of a new and improved rat …
Impaired renal hemodynamics and glomerular hyperfiltration contribute to hypertension-induced renal injury
L Fan, W Gao, BV Nguyen… - American Journal …, 2020 - journals.physiology.org
Recently, we reported a mutation in γ-adducin (ADD3) was associated with an impaired
myogenic response of the afferent arteriole and hypertension-induced chronic kidney …
myogenic response of the afferent arteriole and hypertension-induced chronic kidney …