Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms
A Anjum, MD Yazid, M Fauzi Daud, J Idris… - International journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes
major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and …
major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and …
Drug delivery to the central nervous system
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …
development remains challenging, with high costs, long pathways to clinical use and high …
The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data
JH Badhiwala, JR Wilson, CD Witiw, JS Harrop… - The Lancet …, 2021 - thelancet.com
Background Although there is a strong biological rationale for early decompression of the
injured spinal cord, the influence of the timing of surgical decompression for acute spinal …
injured spinal cord, the influence of the timing of surgical decompression for acute spinal …
Progression in translational research on spinal cord injury based on microenvironment imbalance
B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …
and imposes a considerable burden on patients, families, and society. Repair of the injured …
Acute traumatic spinal cord injury
I Eli, DP Lerner, Z Ghogawala - Neurologic clinics, 2021 - neurologic.theclinics.com
Acute traumatic spinal cord injury (SCI) is typically associated with devastating outcomes.
The injury to the spinal cord results in damage to motor, sensory, and autonomic functions of …
The injury to the spinal cord results in damage to motor, sensory, and autonomic functions of …
Modern medical management of spinal cord injury
M Karsy, G Hawryluk - Current Neurology and Neuroscience Reports, 2019 - Springer
Abstract Purpose of Review Spinal cord injury (SCI) shows an incidence of 10.4–83
cases/million/year globally and remains a significant source of morbidity and cost to society …
cases/million/year globally and remains a significant source of morbidity and cost to society …
Time is spine: a review of translational advances in spinal cord injury: JNSPG 75th Anniversary Invited Review Article
JH Badhiwala, CS Ahuja, MG Fehlings - Journal of Neurosurgery: Spine, 2018 - thejns.org
Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical,
emotional, and economic consequences for patients, families, and society at large. Timely …
emotional, and economic consequences for patients, families, and society at large. Timely …
Assessment and management of acute spinal cord injury: From point of injury to rehabilitation
LD Hachem, CS Ahuja, MG Fehlings - The journal of spinal cord …, 2017 - Taylor & Francis
Context: Spinal cord injury (SCI) is a devastating condition that can lead to significant
neurological impairment and reduced quality of life. Despite advancements in our …
neurological impairment and reduced quality of life. Despite advancements in our …
Acute spinal cord injury: Pathophysiology and pharmacological intervention
Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …
afflict individuals. For a number of years, extensive studies have been conducted to clarify …
High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury
W Li, J Chen, S Zhao, T Huang, H Ying… - Nature …, 2022 - nature.com
Drug delivery systems with high content of drug can minimize excipients administration,
reduce side effects, improve therapeutic efficacy and/or promote patient compliance …
reduce side effects, improve therapeutic efficacy and/or promote patient compliance …