Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms

A Anjum, MD Yazid, M Fauzi Daud, J Idris… - International journal of …, 2020 - mdpi.com
Spinal cord injury (SCI) is a destructive neurological and pathological state that causes
major motor, sensory and autonomic dysfunctions. Its pathophysiology comprises acute and …

Drug delivery to the central nervous system

E Nance, SH Pun, R Saigal, DL Sellers - Nature Reviews Materials, 2022 - nature.com
Despite the rising global incidence of central nervous system (CNS) disorders, CNS drug
development remains challenging, with high costs, long pathways to clinical use and high …

The influence of timing of surgical decompression for acute spinal cord injury: a pooled analysis of individual patient data

JH Badhiwala, JR Wilson, CD Witiw, JS Harrop… - The Lancet …, 2021 - thelancet.com
Background Although there is a strong biological rationale for early decompression of the
injured spinal cord, the influence of the timing of surgical decompression for acute spinal …

Progression in translational research on spinal cord injury based on microenvironment imbalance

B Fan, Z Wei, S Feng - Bone research, 2022 - nature.com
Spinal cord injury (SCI) leads to loss of motor and sensory function below the injury level
and imposes a considerable burden on patients, families, and society. Repair of the injured …

Acute traumatic spinal cord injury

I Eli, DP Lerner, Z Ghogawala - Neurologic clinics, 2021 - neurologic.theclinics.com
Acute traumatic spinal cord injury (SCI) is typically associated with devastating outcomes.
The injury to the spinal cord results in damage to motor, sensory, and autonomic functions of …

Modern medical management of spinal cord injury

M Karsy, G Hawryluk - Current Neurology and Neuroscience Reports, 2019 - Springer
Abstract Purpose of Review Spinal cord injury (SCI) shows an incidence of 10.4–83
cases/million/year globally and remains a significant source of morbidity and cost to society …

Time is spine: a review of translational advances in spinal cord injury: JNSPG 75th Anniversary Invited Review Article

JH Badhiwala, CS Ahuja, MG Fehlings - Journal of Neurosurgery: Spine, 2018 - thejns.org
Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical,
emotional, and economic consequences for patients, families, and society at large. Timely …

Assessment and management of acute spinal cord injury: From point of injury to rehabilitation

LD Hachem, CS Ahuja, MG Fehlings - The journal of spinal cord …, 2017 - Taylor & Francis
Context: Spinal cord injury (SCI) is a devastating condition that can lead to significant
neurological impairment and reduced quality of life. Despite advancements in our …

Acute spinal cord injury: Pathophysiology and pharmacological intervention

Y Zhang, A Al Mamun, Y Yuan… - Molecular …, 2021 - spandidos-publications.com
Spinal cord injury (SCI) is one of the most debilitating of all the traumatic conditions that
afflict individuals. For a number of years, extensive studies have been conducted to clarify …

High drug-loaded microspheres enabled by controlled in-droplet precipitation promote functional recovery after spinal cord injury

W Li, J Chen, S Zhao, T Huang, H Ying… - Nature …, 2022 - nature.com
Drug delivery systems with high content of drug can minimize excipients administration,
reduce side effects, improve therapeutic efficacy and/or promote patient compliance …