Senescence and cancer—role and therapeutic opportunities
Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …
The interplay between apoptosis and cellular senescence: Bcl-2 family proteins as targets for cancer therapy
A Basu - Pharmacology & therapeutics, 2022 - Elsevier
Cell death by apoptosis and permanent cell cycle arrest by senescence serve as barriers to
the development of cancer. Chemotherapeutic agents not only induce apoptosis, they can …
the development of cancer. Chemotherapeutic agents not only induce apoptosis, they can …
NKG2D-CAR T cells eliminate senescent cells in aged mice and nonhuman primates
D Yang, B Sun, S Li, W Wei, X Liu, X Cui… - Science Translational …, 2023 - science.org
Cellular senescence, characterized by stable cell cycle arrest, plays an important role in
aging and age-associated pathologies. Eliminating senescent cells rejuvenates aged …
aging and age-associated pathologies. Eliminating senescent cells rejuvenates aged …
A senescence-centric view of aging: implications for longevity and disease
Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …
alterations and secretion of proinflammatory cytokines and molecules. From their initial …
Roles of extracellular vesicles in the aging microenvironment and age‐related diseases
Y Yin, H Chen, Y Wang, L Zhang… - Journal of extracellular …, 2021 - Wiley Online Library
Cellular senescence is a persistently hypoproliferative state with diverse stressors in a
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …
specific aging microenvironment. Senescent cells have a double‐edged sword effect: they …
The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
Senescent cells in cancer therapy: friends or foes?
Several cancer interventions induce DNA damage and promote senescence in cancer and
nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors …
nonmalignant cells. Senescent cells secrete a collection of proinflammatory factors …
Bone-matrix mineralization dampens integrin-mediated mechanosignalling and metastatic progression in breast cancer
In patients with breast cancer, lower bone mineral density increases the risk of bone
metastasis. Although the relationship between bone-matrix mineralization and tumour-cell …
metastasis. Although the relationship between bone-matrix mineralization and tumour-cell …
Overcoming the senescence‐associated secretory phenotype (SASP): a complex mechanism of resistance in the treatment of cancer
CR Chambers, S Ritchie, BA Pereira… - Molecular …, 2021 - Wiley Online Library
Senescence is a cellular state in which cells undergo persistent cell cycle arrest in response
to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of …
to nonlethal stress. In the treatment of cancer, senescence induction is a potent method of …
Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain
Chemotherapy‐induced cognitive impairment (“chemobrain”) is a frequent side‐effect in
cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX …
cancer survivors treated with paclitaxel (PTX). The mechanisms responsible for PTX …