The pathogenesis of rheumatoid arthritis

S Alivernini, GS Firestein, IB McInnes - Immunity, 2022 - cell.com
Significant recent progress in understanding rheumatoid arthritis (RA) pathogenesis has led
to improved treatment and quality of life. The introduction of targeted-biologic and-synthetic …

[HTML][HTML] Role of reactive oxygen species and mitochondrial damage in rheumatoid arthritis and targeted drugs

W Jing, C Liu, C Su, L Liu, P Chen, X Li… - Frontiers in …, 2023 - frontiersin.org
Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovial
inflammation, pannus formation, and bone and cartilage damage. It has a high disability …

Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications

U Fearon, MM Hanlon, A Floudas… - Nature Reviews …, 2022 - nature.com
Activation of endothelium and immune cells is fundamental to the initiation of autoimmune
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …

[PDF][PDF] Pathogenesis of rheumatoid arthritis: one year in review 2023

FM Mariani, I Martelli, F Pistone… - Clin Exp …, 2023 - clinexprheumatol.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by local and
systemic inflammation. The complex interplay between immune cells and soluble mediators …

Therapeutic effects of mesenchymal/stromal stem cells and their derived extracellular vesicles in rheumatoid arthritis

D Tsiapalis, A Floudas, T Tertel… - Stem Cells …, 2023 - academic.oup.com
Currently available therapies for rheumatoid arthritis (RA) are inadequate to alleviate the
inflammation and reduce joint damage. While the immune-regulatory effect of human …

[HTML][HTML] The search for the pathogenic T cells in the joint of rheumatoid arthritis: Which T-cell subset drives autoimmune inflammation?

H Yamada - International journal of molecular sciences, 2023 - mdpi.com
Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting systemic synovial
tissues, leading to the destruction of multiple joints. Its etiology is still unknown, but T-cell …

[HTML][HTML] Impaired immune tolerance mediated by reduced Tfr cells in rheumatoid arthritis linked to gut microbiota dysbiosis and altered metabolites

R Wu, D Wang, L Cheng, R Su, B Li, C Fan… - Arthritis Research & …, 2024 - Springer
Background Patients with rheumatoid arthritis (RA) showed impaired immune tolerance
characterized by reduced follicular regulatory T (Tfr) cells, and they also exhibited altered …

Peripheral CD4+/CD8+ T cell composition distinct from healthy individuals is shared by ankylosing spondylitis and rheumatoid arthritis

L Gui, X Luo, L Zhou, Q Wei, J Gu - International Journal of …, 2023 - Wiley Online Library
Objective Ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are chronic inflammatory
joint diseases, linking to the alterations of immune cells. We attempted to assess whether the …

Comparison and subsets analysis of peripheral CD4+ T cells in patients with psoriasis and psoriatic arthritis

W Gao, Y Lei, X Guo, Y Luo, Z Zhang, Y Xi, W Wang… - Molecular …, 2023 - Elsevier
Psoriatic arthritis (PsA) is a disease that transformed from psoriasis (PsO), and its underlying
mechanisms are still not fully understood. Overactivation of the immune system is a key …

[HTML][HTML] Current situation and trend of non-coding RNA in rheumatoid arthritis: a review and bibliometric analysis

Z Wei, H Li, S Lv, J Yang - Frontiers in Immunology, 2024 - frontiersin.org
Background Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that
affects multiple joints and has adverse effects on various organs throughout the body, often …