Enhancer of zeste homolog 2 (EZH2) plays critical roles in a range of biological processes
including organ development and homeostasis, epigenomic and transcriptomic regulation …

The polycomb repressive complex 2 (PRC2) consists of three core components EZH2,
SUZ12 and EED. EZH2 catalyzes the methylation of lysine 27 of histone H3, a modification …

Simple Summary Cisplatin is a chemotherapy drug widely used in the treatment of different
cancer types. However, cisplatin displays a high range of toxicity and its use usually leads to …

Mutations in chromatin modifying genes frequently occur in many kinds of cancer. Most
mechanistic studies focus on their canonical functions, while therapeutic approaches target …

Cancer cell heterogeneity is a major driver of therapy resistance. To characterize resistant
cells and their vulnerabilities, we studied the PLZF-RARA variant of acute promyelocytic …

Prostate cancer-associated ncRNA transcript 6 (PCAT6) is a long intergenic noncoding RNA
that is involved in the progression of prostate and lung cancer, acting as a potential …

Acquired chromosomal DNA copy gains are a feature of many tumors; however, the
mechanisms that underpin oncogene amplification are poorly understood. Recent studies …

Current reports refer to the role of long noncoding RNA (lncRNA) prostate androgen-
regulated transcript 1 (PART1) as a tumor suppressor in some types of cancer but as an …

Following acute infection, herpes simplex virus 1 (HSV-1) lytic cycle viral gene expression is
silenced; consequently, lifelong latency in neurons is established. Certain external stimuli …

Polycystic ovary syndrome (PCOS) appears to have a genetic predisposition and a fetal
origin. We compared the expression levels of 25 PCOS candidate genes from adult control …