Developmental origins of metabolic diseases
Almost 2 billion adults in the world are overweight, and more than half of them are classified
as obese, while nearly one-third of children globally experience poor growth and …
as obese, while nearly one-third of children globally experience poor growth and …
Placental origins of chronic disease
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …
events during their intrauterine phase of development. Biologically this should not be …
[HTML][HTML] Effects of maternal obesity on placental function and fetal development
Obesity has reached epidemic proportions and pregnancies in obese mothers have
increased risk for complications including gestational diabetes, hypertensive disorders …
increased risk for complications including gestational diabetes, hypertensive disorders …
Placental function in maternal obesity
Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …
Maternal obesity and diabetes mellitus as risk factors for congenital heart disease in the offspring
E Helle, JR Priest - Journal of the American Heart Association, 2020 - Am Heart Assoc
Congenital heart disease (CHD) is the most common anatomical malformation occurring live‐
born infants and an increasing cause of morbidity and mortality across the lifespan and …
born infants and an increasing cause of morbidity and mortality across the lifespan and …
Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta
BV Natale, KN Gustin, K Lee, AC Holloway… - Scientific reports, 2020 - nature.com
Abstract 1 in 5 women report cannabis use during pregnancy, with nausea cited as their
primary motivation. Studies show that (-)-△ 9–tetrahydrocannabinol (Δ9-THC), the major …
primary motivation. Studies show that (-)-△ 9–tetrahydrocannabinol (Δ9-THC), the major …
Metabolic landscape in cardiac aging: insights into molecular biology and therapeutic implications
S Xie, SC Xu, W Deng, Q Tang - Signal transduction and targeted …, 2023 - nature.com
Cardiac aging is evident by a reduction in function which subsequently contributes to heart
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …
failure. The metabolic microenvironment has been identified as a hallmark of malignancy …
Adiponectin supplementation in pregnant mice prevents the adverse effects of maternal obesity on placental function and fetal growth
Mothers with obesity or gestational diabetes mellitus have low circulating levels of
adiponectin (ADN) and frequently deliver large babies with increased fat mass, who are …
adiponectin (ADN) and frequently deliver large babies with increased fat mass, who are …
Placental function and the development of fetal overgrowth and fetal growth restriction
The developing fetus undergoes a dynamic period of rapid growth that is responsive to
changes in the in utero environment that may contribute to the development of fetal growth …
changes in the in utero environment that may contribute to the development of fetal growth …
Effects of maternal obesity and gestational diabetes mellitus on the placenta: current knowledge and targets for therapeutic interventions
S Bedell, J Hutson, B de Vrijer… - Current vascular …, 2021 - ingentaconnect.com
Obesity and gestational diabetes mellitus (GDM) are becoming more common among
pregnant women worldwide and are individually associated with a number of placenta …
pregnant women worldwide and are individually associated with a number of placenta …