Engineered cell culture microenvironments for mechanobiology studies of brain neural cells

L Castillo Ransanz, PFJ Van Altena… - … in bioengineering and …, 2022 - frontiersin.org
The biomechanical properties of the brain microenvironment, which is composed of different
neural cell types, the extracellular matrix, and blood vessels, are critical for normal brain …

Recent advances in atomic force microscopy for assessing the nanomechanical properties of food materials

S Cárdenas-Pérez, JJ Chanona-Pérez… - Trends in food science & …, 2019 - Elsevier
Background Atomic force microscopy (AFM) has been used to study the molecular structure
of biological materials. AFM has become a novel tool that allows measurement of …

[HTML][HTML] The biochemical, nanomechanical and chemometric signatures of brain cancer

H Abramczyk, A Imiela - Spectrochimica Acta Part A: Molecular and …, 2018 - Elsevier
Raman spectroscopy and imaging combined with AFM topography and mechanical
indentation by AFM have been shown to be an effective tool for analysis and discrimination …

[HTML][HTML] Nano-scientific application of atomic force microscopy in pathology: from molecules to tissues

TM Kiio, S Park - International Journal of Medical Sciences, 2020 - ncbi.nlm.nih.gov
The advantages of atomic force microscopy (AFM) in biological research are its high
imaging resolution, sensitivity, and ability to operate in physiological conditions. Over the …

Enhanced protection of biological membranes during lipid peroxidation: Study of the interactions between flavonoid loaded mesoporous silica nanoparticles and …

L Mandić, A Sadžak, V Strasser, G Baranović… - International journal of …, 2019 - mdpi.com
Flavonoids, polyphenols with anti-oxidative activity have high potential as novel therapeutics
for neurodegenerative disease, but their applicability is rendered by their poor water …

Non-contact elastography methods in mechanobiology: a point of view

S Caponi, A Passeri, G Capponi, D Fioretto… - European Biophysics …, 2022 - Springer
In recent decades, mechanobiology has emerged as a novel perspective in the context of
basic biomedical research. It is now widely recognized that living cells respond not only to …

Red blood cell stiffness and adhesion are species-specific properties strongly affected by temperature and medium changes in single cell force spectroscopy

D Baier, T Müller, T Mohr, U Windberger - Molecules, 2021 - mdpi.com
Besides human red blood cells (RBC), a standard model used in AFM-single cell force
spectroscopy (SCFS), little is known about apparent Young's modulus (Ea) or adhesion of …

Single‐cell encapsulation via click‐chemistry alters production of paracrine factors from neural progenitor cells

B Oh, V Swaminathan, A Malkovskiy… - Advanced …, 2020 - Wiley Online Library
Extracellular matrix (ECM) properties affect multiple cellular processes such as cell survival,
proliferation, and protein synthesis. Thus, a polymeric‐cell delivery system with the ability to …

Neurotoxic effect of flavonol myricetin in the presence of excess copper

A Sadžak, I Vlašić, Z Kiralj, M Batarelo, N Oršolić… - Molecules, 2021 - mdpi.com
Oxidative stress (OS) induced by the disturbed homeostasis of metal ions is one of the
pivotal factors contributing to neurodegeneration. The aim of the present study was to …

A soft mechanical phenotype of SH-SY5Y neuroblastoma and primary human neurons is resilient to oligomeric Aβ (1–42) injury

TM Kruger, KJ Bell, TI Lansakara… - ACS chemical …, 2020 - ACS Publications
Aggregated amyloid beta (Aβ) is widely reported to cause neuronal dystrophy and toxicity
through multiple pathways: oxidative stress, disrupting calcium homeostasis, and …