Neddylation, a post-translational modification that conjugates an ubiquitin-like protein
NEDD8 to substrate proteins, is an important biochemical process that regulates protein …

Post-translational modifications of cellular substrates with ubiquitin and ubiquitin-like
proteins (UBLs), including ubiquitin, SUMOs, and neural precursor cell–expressed …

Iron oxide nanoparticles (IONPs) have been increasingly used in biomedical applications,
but the comprehensive understanding of their interactions with biological systems is …

NEDDylation, a post-translational modification through three-step enzymatic cascades,
plays crucial roles in the regulation of diverse biological processes. NEDD8-activating …

Blood–brain barrier (BBB) breakdown and inflammation occurring at the BBB have a key,
mainly a deleterious role in the pathophysiology of ischemic stroke. Neddylation is a …

Protein neddylation is a post-translational modification, and its best recognized substrates
are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs) …

Circadian rhythms are natural rhythms that widely exist in all creatures, and regulate the
processes and physiological functions of various biochemical reactions. The circadian clock …

NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an
ubiquitin-like protein that is covalently attached to a lysine residue of a protein substrate …

Ubiquitination is a highly conserved post-translational modification in eukaryotes, well
known for targeting proteins for degradation by the 26S proteasome. Proteins destined for …

Neddylation is a post-translational protein modification associated with cancer development.
MLN4924 is a neddylation inhibitor currently under investigation in multiple phase I studies …