Current gaps in sepsis immunology: new opportunities for translational research

I Rubio, MF Osuchowski, M Shankar-Hari… - The Lancet infectious …, 2019 - thelancet.com
Increasing evidence supports a central role of the immune system in sepsis, but the current
view of how sepsis affects immunity, and vice versa, is still rudimentary. The European …

CyTOF® for the Masses

A Iyer, AAJ Hamers, AB Pillai - Frontiers in immunology, 2022 - frontiersin.org
Mass cytometry has revolutionized immunophenotyping, particularly in exploratory settings
where simultaneous breadth and depth of characterization of immune populations is needed …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells

Q Hammer, T Rückert, EM Borst, J Dunst… - Nature …, 2018 - nature.com
Natural killer (NK) cells are innate lymphocytes that lack antigen-specific rearranged
receptors, a hallmark of adaptive lymphocytes. In some people infected with human …

Interleukin-22 protects intestinal stem cells against genotoxic stress

K Gronke, PP Hernández, J Zimmermann, CSN Klose… - Nature, 2019 - nature.com
Environmental genotoxic factors pose a challenge to the genomic integrity of epithelial cells
at barrier surfaces that separate host organisms from the environment. They can induce …

Advances in cryopreservation of bull sperm

MR Ugur, A Saber Abdelrahman, HC Evans… - Frontiers in veterinary …, 2019 - frontiersin.org
Cryopreservation of semen and artificial insemination have an important, positive impact on
cattle production, and product quality. Through the use of cryopreserved semen and artificial …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Polyamines control eIF5A hypusination, TFEB translation, and autophagy to reverse B cell senescence

H Zhang, G Alsaleh, J Feltham, Y Sun, G Napolitano… - Molecular cell, 2019 - cell.com
Failure to make adaptive immune responses is a hallmark of aging. Reduced B cell function
leads to poor vaccination efficacy and a high prevalence of infections in the elderly. Here we …

Tissue-resident memory T cells invade the brain parenchyma in multiple sclerosis white matter lesions

NL Fransen, CC Hsiao, M van der Poel… - Brain, 2020 - academic.oup.com
Multiple sclerosis is a chronic inflammatory, demyelinating disease, although it has been
suggested that in the progressive late phase, inflammatory lesion activity declines. We …

T cell assays differentiate clinical and subclinical SARS-CoV-2 infections from cross-reactive antiviral responses

A Ogbe, B Kronsteiner, DT Skelly, M Pace… - Nature …, 2021 - nature.com
Identification of protective T cell responses against SARS-CoV-2 requires distinguishing
people infected with SARS-CoV-2 from those with cross-reactive immunity to other …