The case of complement activation in COVID-19 multiorgan impact
The novel coronavirus disease COVID-19 originates in the lungs, but it may extend to other
organs, causing, in severe cases, multiorgan damage, including cardiac injury and acute …
organs, causing, in severe cases, multiorgan damage, including cardiac injury and acute …
[HTML][HTML] Sepsis and septic shock
RS Hotchkiss, LL Moldawer, SM Opal… - Nature reviews Disease …, 2016 - nature.com
For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …
SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation
Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 …
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 …
[HTML][HTML] The SARS-coronavirus infection cycle: a survey of viral membrane proteins, their functional interactions and pathogenesis
NA Wong, MH Saier Jr - International journal of molecular sciences, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel epidemic
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …
[HTML][HTML] COVID‐19: a collision of complement, coagulation and inflammatory pathways
AJ Chauhan, LJ Wiffen, TP Brown - Journal of Thrombosis and …, 2020 - Elsevier
COVID‐19 is frequently accompanied by a hypercoagulable inflammatory state with
microangiopathic pulmonary changes that can precede the diffuse alveolar damage …
microangiopathic pulmonary changes that can precede the diffuse alveolar damage …
[HTML][HTML] Proteomic and metabolomic characterization of COVID-19 patient sera
B Shen, X Yi, Y Sun, X Bi, J Du, C Zhang, S Quan… - Cell, 2020 - cell.com
Early detection and effective treatment of severe COVID-19 patients remain major
challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID …
challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID …
[HTML][HTML] A role for neutrophils in viral respiratory disease
JV Camp, CB Jonsson - Frontiers in immunology, 2017 - frontiersin.org
Neutrophils are immune cells that are well known to be present during many types of lung
diseases associated with acute respiratory distress syndrome (ARDS) and may contribute to …
diseases associated with acute respiratory distress syndrome (ARDS) and may contribute to …
High level of neutrophil extracellular traps correlates with poor prognosis of severe influenza A infection
L Zhu, L Liu, Y Zhang, L Pu, J Liu, X Li… - The Journal of …, 2018 - academic.oup.com
Background Most patients with severe infection with influenza A virus (IAV) progress to acute
respiratory distress syndrome and even multiple organ dysfunction syndrome (MODS) …
respiratory distress syndrome and even multiple organ dysfunction syndrome (MODS) …
[HTML][HTML] Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome
JA Englert, C Bobba, RM Baron - JCI insight, 2019 - ncbi.nlm.nih.gov
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …
Role of neutrophils in acute viral infection
Y Ma, Y Zhang, L Zhu - Immunity, inflammation and disease, 2021 - Wiley Online Library
Neutrophils play multiple roles in acute viral infections. They restrict viral replication and
diffusion through phagocytosis, degranulation, respiratory burst, secretion of cytokines, and …
diffusion through phagocytosis, degranulation, respiratory burst, secretion of cytokines, and …