The case of complement activation in COVID-19 multiorgan impact

M Noris, A Benigni, G Remuzzi - Kidney international, 2020 - Elsevier
The novel coronavirus disease COVID-19 originates in the lungs, but it may extend to other
organs, causing, in severe cases, multiorgan damage, including cardiac injury and acute …

[HTML][HTML] Sepsis and septic shock

RS Hotchkiss, LL Moldawer, SM Opal… - Nature reviews Disease …, 2016 - nature.com
For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

SARS-CoV-2 drives JAK1/2-dependent local complement hyperactivation

B Yan, T Freiwald, D Chauss, L Wang, E West… - Science …, 2021 - science.org
Patients with coronavirus disease 2019 (COVID-19) present a wide range of acute clinical
manifestations affecting the lungs, liver, kidneys, and gut. Angiotensin-converting enzyme 2 …

[HTML][HTML] The SARS-coronavirus infection cycle: a survey of viral membrane proteins, their functional interactions and pathogenesis

NA Wong, MH Saier Jr - International journal of molecular sciences, 2021 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a novel epidemic
strain of Betacoronavirus that is responsible for the current viral pandemic, coronavirus …

[HTML][HTML] COVID‐19: a collision of complement, coagulation and inflammatory pathways

AJ Chauhan, LJ Wiffen, TP Brown - Journal of Thrombosis and …, 2020 - Elsevier
COVID‐19 is frequently accompanied by a hypercoagulable inflammatory state with
microangiopathic pulmonary changes that can precede the diffuse alveolar damage …

[HTML][HTML] Proteomic and metabolomic characterization of COVID-19 patient sera

B Shen, X Yi, Y Sun, X Bi, J Du, C Zhang, S Quan… - Cell, 2020 - cell.com
Early detection and effective treatment of severe COVID-19 patients remain major
challenges. Here, we performed proteomic and metabolomic profiling of sera from 46 COVID …

[HTML][HTML] A role for neutrophils in viral respiratory disease

JV Camp, CB Jonsson - Frontiers in immunology, 2017 - frontiersin.org
Neutrophils are immune cells that are well known to be present during many types of lung
diseases associated with acute respiratory distress syndrome (ARDS) and may contribute to …

High level of neutrophil extracellular traps correlates with poor prognosis of severe influenza A infection

L Zhu, L Liu, Y Zhang, L Pu, J Liu, X Li… - The Journal of …, 2018 - academic.oup.com
Background Most patients with severe infection with influenza A virus (IAV) progress to acute
respiratory distress syndrome and even multiple organ dysfunction syndrome (MODS) …

[HTML][HTML] Integrating molecular pathogenesis and clinical translation in sepsis-induced acute respiratory distress syndrome

JA Englert, C Bobba, RM Baron - JCI insight, 2019 - ncbi.nlm.nih.gov
Sepsis-induced acute respiratory distress syndrome (ARDS) has high morbidity and
mortality and arises after lung infection or infection at extrapulmonary sites. An aberrant host …

Role of neutrophils in acute viral infection

Y Ma, Y Zhang, L Zhu - Immunity, inflammation and disease, 2021 - Wiley Online Library
Neutrophils play multiple roles in acute viral infections. They restrict viral replication and
diffusion through phagocytosis, degranulation, respiratory burst, secretion of cytokines, and …