[HTML][HTML] Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. They
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
regulate self-/non-self-discrimination, are key elements of cellular communication, cancer …
Toward SERS-based therapeutic drug monitoring in clinical settings: Recent developments and trends
C Liu, S Weber, R Peng, L Wu, W Zhang… - TrAC Trends in …, 2023 - Elsevier
Therapeutic drug monitoring (TDM) plays an important role in ensuring optimal drug therapy
and has become increasingly important in clinical practice. In the first part of this review …
and has become increasingly important in clinical practice. In the first part of this review …
[HTML][HTML] Cannabis constituents interact at the drug efflux pump BCRP to markedly increase plasma cannabidiolic acid concentrations
LL Anderson, MG Etchart, D Bahceci… - Scientific reports, 2021 - nature.com
Cannabis is a complex mixture of hundreds of bioactive molecules. This provides the
potential for pharmacological interactions between cannabis constituents, a phenomenon …
potential for pharmacological interactions between cannabis constituents, a phenomenon …
Current state and future perspective of cardiovascular medicines derived from natural products
C Zhao, S Li, J Zhang, Y Huang, L Zhang… - Pharmacology & …, 2020 - Elsevier
The contribution of natural products (NPs) to cardiovascular medicine has been extensively
documented, and many have been used for centuries. Cardiovascular disease (CVD) is the …
documented, and many have been used for centuries. Cardiovascular disease (CVD) is the …
[HTML][HTML] Targeting hypoxia-inducible factors with 32-134D safely and effectively treats diabetic eye disease in mice
J Zhang, D Sharma, A Dinabandhu… - The Journal of …, 2023 - Am Soc Clin Investig
Many patients with diabetic eye disease respond inadequately to anti-VEGF therapies,
implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels …
implicating additional vasoactive mediators in its pathogenesis. We demonstrate that levels …
Sensitive CRISPR-Cas12a-assisted immunoassay for small molecule detection in homogeneous solution
F Zhu, Q Zhao - Analytical Chemistry, 2023 - ACS Publications
Sensitive detection of small molecules is crucial for many applications, like biomedical
diagnosis, food safety, and environmental analysis. Here, we describe a sensitive CRISPR …
diagnosis, food safety, and environmental analysis. Here, we describe a sensitive CRISPR …
[HTML][HTML] The Role of Hypoxia and Cancer Stem Cells in Development of Glioblastoma
T Shi, J Zhu, X Zhang, X Mao - Cancers, 2023 - mdpi.com
Simple Summary As one of most malignant tumors in brain, glioblastoma (GBM) is lack of
effective treatment and the prognosis of GBM patients is still very poor despite accumulated …
effective treatment and the prognosis of GBM patients is still very poor despite accumulated …
[HTML][HTML] Oleandrin: a systematic review of its natural sources, structural properties, detection methods, pharmacokinetics and toxicology
J Zhai, X Dong, F Yan, H Guo, J Yang - Frontiers in Pharmacology, 2022 - frontiersin.org
Oleandrin is a highly lipid-soluble cardiac glycoside isolated from the plant Nerium oleander
(Apocynaceae) and is used as a traditional herbal medicine due to its excellent …
(Apocynaceae) and is used as a traditional herbal medicine due to its excellent …
Neuroprotective strategies for neonatal hypoxic-ischemic brain damage: Current status and challenges
Q You, X Lan, N Liu, J Du, L Ma, J Yang, J Niu… - European Journal of …, 2023 - Elsevier
Neonatal hypoxic-ischemic brain damage (HIBD) is a prominent contributor to both
immediate mortality and long-term impairment in newborns. The elusive nature of the …
immediate mortality and long-term impairment in newborns. The elusive nature of the …
Cellular signaling in the hypoxic cancer microenvironment: Implications for drug resistance and therapeutic targeting
The rewiring of cellular metabolism is a defining characteristic of cancer, as tumor cells
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …
adapt to acquire essential nutrients from a nutrient-poor environment to sustain their viability …