Bulbar impairment represents a hallmark feature of Amyotrophic Lateral Sclerosis (ALS) that
significantly impacts survival and quality of life. Speech and swallowing dysfunction are key …

Diffusion-tensor imaging (DTI) is a noninvasive medical imaging tool used to investigate the
structure of white matter. The signal contrast in DTI is generated by differences in the …

Objective To examine neurofilament (Nf) concentrations according to symptom onset and
clinical diagnostic certainty categories of amyotrophic lateral sclerosis (ALS). Methods We …

Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease, with large
variation in survival between patients. Currently, it remains rather difficult to predict survival …

Objective Our objective was to study the hypothalamic volume in a cohort of patients with
amyotrophic lateral sclerosis (ALS) including symptomatic and presymptomatic ALS …

Background: Amyotrophic Lateral Sclerosis (ALS) is a relentlessly progressive
neurodegenerative condition with limited therapeutic options at present. Survival from …

Background and purpose Considerable functional reorganization takes place in
amyotrophic lateral sclerosis (ALS) in face of relentless structural degeneration. This study …

The description of group-level, genotype-and phenotype-associated imaging traits is
academically important, but the practical demands of clinical neurology centre on the …

Although the past two decades have produced exciting discoveries in the genetics and
pathology of amyotrophic lateral sclerosis (ALS), progress in developing an effective therapy …

Objective To evaluate progressive white matter (WM) degeneration in amyotrophic lateral
sclerosis (ALS). Methods Sixty-six patients with ALS and 43 healthy controls were enrolled …