In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Evolvability is the ability of a biological system to produce phenotypic variation that is both
heritable and adaptive. It has long been the subject of anecdotal observations and …

The same mutation can have different effects in different individuals. One important reason
for this is that the outcome of a mutation can depend on the genetic context in which it …

Multiplex assays of variant effect (MAVEs), such as deep mutational scans and massively
parallel reporter assays, test thousands of sequence variants in a single experiment. Despite …

Determining the three-dimensional structures of macromolecules is a major goal of
biological research, because of the close relationship between structure and function; …

Over the last decade, a rich variety of massively parallel assays have revolutionized our
understanding of how biological sequences encode quantitative molecular phenotypes …

Given the constantly improving cost and speed of genome sequencing, it is reasonable to
expect that personal genomes will soon be known for many millions of humans. This stands …

Influenza remains a persistent public health challenge, because the rapid evolution of
influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual …

Characterizing the fitness landscape, a representation of fitness for a large set of genotypes,
is key to understanding how genetic information is interpreted to create functional …

Deep mutational scanning (DMS) enables multiplexed measurement of the effects of
thousands of variants of proteins, RNAs, and regulatory elements. Here, we present a …