Conotoxins: chemistry and biology
The venom of the marine predatory cone snails (genus Conus) has evolved for prey capture
and defense, providing the basis for survival and rapid diversification of the now estimated …
and defense, providing the basis for survival and rapid diversification of the now estimated …
Cone snails: A big store of conotoxins for novel drug discovery
Marine drugs have developed rapidly in recent decades. Cone snails, a group of more than
700 species, have always been one of the focuses for new drug discovery. These venomous …
700 species, have always been one of the focuses for new drug discovery. These venomous …
Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA
The voltage-gated sodium channel Nav1. 2 is responsible for the initiation and propagation
of action potentials in the central nervous system. We report the cryo–electron microscopy …
of action potentials in the central nervous system. We report the cryo–electron microscopy …
Tetrodotoxin, a potential drug for neuropathic and cancer pain relief?
R González-Cano, MC Ruiz-Cantero… - Toxins, 2021 - mdpi.com
Tetrodotoxin (TTX) is a potent neurotoxin found mainly in puffer fish and other marine and
terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically …
terrestrial animals. TTX blocks voltage-gated sodium channels (VGSCs) which are typically …
Neuropathic pain: preclinical and early clinical progress with voltage-gated sodium channel blockers
M Kushnarev, IP Pirvulescu, KD Candido… - Expert opinion on …, 2020 - Taylor & Francis
Introduction Neuropathic pain is a chronic condition that significantly affects the quality of life
of millions of people globally. Most of the pharmacologic treatments currently in use …
of millions of people globally. Most of the pharmacologic treatments currently in use …
Discovery Methodology of Novel Conotoxins from Conus Species
Y Fu, C Li, S Dong, Y Wu, D Zhangsun, S Luo - Marine drugs, 2018 - mdpi.com
Cone snail venoms provide an ideal resource for neuropharmacological tools and drug
candidates discovery, which have become a research hotspot in neuroscience and new …
candidates discovery, which have become a research hotspot in neuroscience and new …
Didecyldimethylammonium bromide: Application to control biofilms of Staphylococcus aureus and Pseudomonas aeruginosa alone and in combination with slightly …
Y Li, H Wang, X Zheng, Z Li, M Wang, K Luo… - Food Research …, 2022 - Elsevier
This project explored the antibacterial mechanism of didecyldimethylammonium bromide
(DDAB) toward Staphylococcus aureus and Pseudomonas aeruginosa, and its removal …
(DDAB) toward Staphylococcus aureus and Pseudomonas aeruginosa, and its removal …
Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible NaV Channel Inhibitor
Voltage-gated sodium (NaV) channel subtypes, including NaV1. 7, are promising targets for
the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ …
the treatment of neurological diseases, such as chronic pain. Cone snail-derived µ …
Historical perspective of the characterization of conotoxins targeting voltage-gated sodium channels
JR Groome - Marine Drugs, 2023 - mdpi.com
Marine toxins have potent actions on diverse sodium ion channels regulated by
transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic …
transmembrane voltage (voltage-gated ion channels) or by neurotransmitters (nicotinic …
High-throughput identification and analysis of novel conotoxins from three vermivorous cone snails by transcriptome sequencing
G Yao, C Peng, Y Zhu, C Fan, H Jiang, J Chen, Y Cao… - Marine Drugs, 2019 - mdpi.com
The venom of each Conus species consists of a diverse array of neurophysiologically active
peptides, which are mostly unique to the examined species. In this study, we performed high …
peptides, which are mostly unique to the examined species. In this study, we performed high …