Tumor metastases are responsible for approximately 90% of all cancer-related deaths.
Although many patients can be cured, in the US and UK, cancer still causes 730,000 deaths …

Cancer is the final result of uninhibited cell growth that involves an enormous group of
associated diseases. One major aspect of cancer is when cells attack adjacent components …

Integrins are a family of heterodimeric cell surface receptors that are expressed in most cells,
where they mediate cell-cell and cell-extracellular matrix (ECM) interactions. Integrin αvβ6 is …

The diversity of potential applications for protein‐engineered materials has undergone
profound recent expansion through a rapid increase in the library of domains that have been …

Anoïkis is defined as programmed cell death induced by the loss of cell/matrix interactions.
Adhesion to structural glycoproteins of the extracellular matrix is necessary for survival of the …

TGFBIp/βig-h3 protein is an extracellular matrix molecule initially cloned from human
adenocarcinoma cells treated with TGF-β. Its precise function remains obscure but a number …

Transforming growth factor-beta-induced protein (TGFBI, also known as βig-H3 and
keratoepithelin) is an extracellular matrix protein that plays a role in a wide range of …

Atrioventricular valve development commences with an EMT event whereby endocardial
cells transform into mesenchyme. The molecular events that induce this phenotypic change …

Background Acquired resistance to trastuzumab is a major clinical problem in the treatment
of HER2-positive (HER2+) breast cancer patients. The selection of trastuzumab-resistant …

Rationale: Sepsis is a systemic inflammatory condition resulting from bacterial infections; it
has a high mortality rate and limited therapeutic options. Despite extensive research into the …