Significance: During the past decades, thiosemicarbazones were clinically developed for a
variety of diseases, including tuberculosis, viral infections, malaria, and cancer. With regard …

Thiazole, triazole, thio and semicarbazones are privileged motifs that act as
pharmacophores in bioactive compounds for various diseases, such as Tuberculosis (TB) …

Background Novel α-amylase inhibitors play a crucial role in managing diabetes and
obesity, contributing to improved public health by addressing these challenging and …

In the current work, new 1, 3, 4-oxadiazole derivatives were synthesized and investigated for
their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat glioma and NIH/3T3 …

In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives (1–
10) were synthesized and investigated for their cytotoxic effects on A549 human lung …

In an attempt to identify small molecules for targeted therapy of non-small cell lung
carcinoma (NSCLC) and prostate cancer (PCa), new arylidene indanones (1–10) were …

Hyperactivity of urease enzyme induces pathogenesis of peptic ulcers and gastritis. The
excess of urease can be reduced by introducing various inhibitors. The risk of high urease …

Abstract In this study, novel 1-(benzo [d][1, 3] dioxol-5-ylmethyl) piperazine substituted
phthalocyanine Zn (II), Pb (II) and Co (II) complexes (ZnPc, PbPc, CoPc) were synthesized …

In this study, we proposed to design effective multi-target anticancer agents based on the
chelation of nontoxic metals with ligands that possess anticancer activity. In total, five Sn (II) …

Dipeptidyl peptidase-4 (DPP-4) inhibition has been recognized as a promising approach to
develop safe and potent antidiabetic agents for the management of type 2 diabetes. In this …