Skeletal aging

JG Sfeir, MT Drake, S Khosla, JN Farr - Mayo Clinic Proceedings, 2022 - Elsevier
Aging represents the single greatest risk factor for chronic diseases, including osteoporosis,
a skeletal fragility syndrome that increases fracture risk. Optimizing bone strength throughout …

Insights and implications of sexual dimorphism in osteoporosis

YY Zhang, N Xie, XD Sun, EC Nice, YC Liou, C Huang… - Bone research, 2024 - nature.com
Osteoporosis, a metabolic bone disease characterized by low bone mineral density and
deterioration of bone microarchitecture, has led to a high risk of fatal osteoporotic fractures …

DNAzyme nanoconstruct-integrated autonomously-adaptive coatings enhance titanium-implant osteointegration by cooperative angiogenesis and vessel remodeling

M Chen, M Li, X Ren, F Zhou, Y Li, L Tan, Z Luo… - ACS …, 2023 - ACS Publications
Orthopedic implants have a high failure rate due to insufficient interfacial osseointegration,
especially under osteoporotic conditions. Type H vessels are CD31+ EMCN+ capillaries …

[HTML][HTML] S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis

F Liu, L Yuan, L Li, J Yang, J Liu, Y Chen… - Pharmacological …, 2023 - Elsevier
Senescence of bone marrow mesenchymal stem cells (BMSCs) is one of the leading causes
of osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, is highly …

The role of trace elements and minerals in osteoporosis: a review of epidemiological and laboratory findings

AV Skalny, M Aschner, EV Silina, VA Stupin… - Biomolecules, 2023 - mdpi.com
The objective of the present study was to review recent epidemiological and clinical data on
the association between selected minerals and trace elements and osteoporosis, as well as …

A narrative review of diabetic bone disease: Characteristics, pathogenesis, and treatment

B Wu, Z Fu, X Wang, P Zhou, Q Yang… - Frontiers in …, 2022 - frontiersin.org
Recently, the increasing prevalence of diabetes mellitus has made it a major chronic illness
which poses a substantial threat to human health. The prevalence of osteoporosis among …

Purine metabolism-related genes and immunization in thyroid eye disease were validated using bioinformatics and machine learning

Z Wu, Y Gao, L Cao, Q Peng, X Yao - Scientific Reports, 2023 - nature.com
Thyroid eye disease (TED), an autoimmune inflammatory disorder affecting the orbit,
exhibits a range of clinical manifestations. While the disease presentation can vary, cases …

Classical and nonclassical manifestations of primary hyperparathyroidism

G El‐Hajj Fuleihan, M Chakhtoura… - Journal of Bone and …, 2020 - academic.oup.com
This narrative review summarizes data on classical and nonclassical manifestations of
primary hyperparathyroidism (PHPT). It is based on a rigorous literature search, inclusive of …

Synergistic Osteogenic and Antiapoptotic Framework Nucleic Acid Complexes Prevent Diabetic Osteoporosis

L Bai, M Feng, Q Zhang, Z Cai, Q Li, Y Li… - Advanced Functional …, 2024 - Wiley Online Library
Diabetes mellitus (DM) is characterized by elevated blood glucose and advanced glycation
end product (AGEs) levels. Increased AGEs in bone tissue inhibit osteogenic differentiation …

Computational Study of the Interaction of C12P12 and C12N12 Nanocages with Alendronate Drug Molecule

L Hitler, JF Eze, AD Nwagu, HO Edet… - …, 2023 - Wiley Online Library
The utilization of nanomaterials as efficient delivery systems to specific metabolic sites is
essential for harnessing the utmost therapeutic potency of drugs leading to a tremendous …