Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

The calcium ion (Ca2+) is the simplest and most versatile intracellular messenger known.
The discovery of Ca2+ sparks and a related family of elementary Ca2+ signaling events has …

Many tissues harbor quiescent stem cells that are activated upon injury, subsequently
proliferating and differentiating to repair tissue damage. Mechanisms by which stem cells …

Duchenne muscular dystrophy (DMD) is a degenerative muscle disease caused by genetic
mutations that lead to the disruption of dystrophin in muscle fibers. There is no curative …

Duchenne muscular dystrophy is characterized by progressive muscle weakness and early
death resulting from dystrophin deficiency. Loss of dystrophin results in disruption of a large …

Duchenne muscular dystrophy (DMD) is a fatal X-linked degenerative muscle disease
caused by the absence of the microtubule-associated protein dystrophin, which results in a …

Calcium-induced calcium release (CICR) was first discovered in skeletal muscle. CICR is
defined as Ca2+ release by the action of Ca2+ alone without the simultaneous action of …

Skeletal muscle-specific stem cells are pivotal for tissue development and regeneration.
Muscle plasticity, inherent in these processes, is also essential for daily life activities. Great …

During exercise, defects in calcium (Ca2+) release have been proposed to impair muscle
function. Here, we show that during exercise in mice and humans, the major Ca2+ release …

Abstract Ryanodine receptors (RyRs)/Ca2+ release channels, on the endoplasmic and
sarcoplasmic reticulum of most cell types, are required for intracellular Ca2+ release …