Traumatic brain injury (TBI) remains a significant source of death and permanent disability,
contributing to nearly one-third of all injury related deaths in the United States and exacting …

Intracranial hypertension (IH) is a clinical condition commonly encountered in the intensive
care unit, which requires immediate treatment. The maintenance of normal intracranial …

Despite substantial investments by government, philanthropic, and commercial sources over
the past several decades, traumatic brain injury (TBI) remains an unmet medical need and a …

Traumatic brain injury (TBI) has historically been viewed as a primarily male problem, since
men are more likely to experience a TBI because of more frequent participation in activities …

Background After central nervous system injury, inflammatory macrophages (M1)
predominate over anti-inflammatory macrophages (M2). The temporal profile of M1/M2 …

Traumatic brain injury (TBI) is one of the leading causes of disability and mortality of people
at all ages. Biochemical, cellular and physiological events that occur during primary injury …

Female sex is associated with improved outcome in experimental brain injury models, such
as traumatic brain injury, ischemic stroke, and intracerebral hemorrhage. This implies female …

Oxidative stress plays a crucial role in traumatic brain injury (TBI) pathogenesis. Reactive
oxygen species (ROS) and reactive nitrogen species (RNS) formed in excess after TBI …

Background Traumatic brain injury (TBI) is an important and growing cause of disability
worldwide, and its cognitive consequences may be particularly significant. This study …

The sex hormone progesterone has been shown to improve outcomes in animal models of a
number of neurologic diseases, including traumatic brain injury, ischemia, spinal cord injury …