Viruses employ a variety of strategies to usurp and control cellular activities through the
orchestrated recruitment of macromolecules to specific cytoplasmic or nuclear …

Virus replication can cause extensive rearrangement of host cell cytoskeletal and membrane
compartments leading to the “cytopathic effect” that has been the hallmark of virus infection …

Stress granules are cytoplasmic ribonucleoprotein granules formed following various
stresses that inhibit translation. They are thought to help protecting untranslated mRNAs …

The PML protein was first identified as part of a fusion product with the retinoic acid receptor
alpha (RAR alpha), resulting from the t (15; 17) chromosomal translocation associated with …

Adenoviruses induce an extensive reorganization of the host cell nucleus during replication.
Such a process results in the assembly of viral and cellular macromolecules into nuclear …

DNA viruses that replicate in the nucleus encompass a range of ubiquitous and clinically
important viruses, from acute pathogens to persistent tumor viruses. These viruses must co …

The E1B 55-kDa oncoprotein of adenovirus enables the virus to overcome restrictions
imposed on viral replication by the cell cycle. Approximately 20% of HeLa cells infected with …

Although microarray and expressed sequence tag (EST)-based approaches have been
used to profile gene expression during baculovirus infection, the response of host genes to …

The product of adenovirus (Ad) type 5 gene IX (pIX) is known to actively participate in the
stability of the viral icosahedron, acting as a capsid cement. We have previously …

A common viral replication strategy is characterized by the assembly of intracellular
compartments that concentrate factors needed for viral replication and simultaneously …