The actin cytoskeleton is essential for cell mechanics and has increasingly been implicated
in the regulation of cell signalling. In B cells, the actin cytoskeleton is extensively coupled to …

B-cell activation plays a crucial part in the immune system and is initiated via interaction
between the B cell receptor (BCR) and specific antigens. In recent years with the help of …

B cell activation is regulated by B cell antigen receptor (BCR) signaling and antigen
internalization in immune synapses. Using large-scale imaging across B cell subsets, we …

Abstract Proteins of the Wiskott-Aldrich syndrome protein (WASP) family play a central role
in regulating actin cytoskeletal dynamics in a wide range of cellular processes. Genetic …

To control their movement, cells need to coordinate actin assembly with the geometric
features of their substrate. Here, we uncover a role for the actin regulator WASP in the 3D …

Abstract The Wiskott–Aldrich syndrome protein (WASP) participates in innate and adaptive
immunity through regulation of actin cytoskeleton‐dependent cellular processes, including …

When B cells encounter antigens on the surface of an antigen-presenting cell (APC), B cell
receptors (BCRs) are gathered into microclusters that recruit signaling enzymes. These …

The small Rho GTPase Cdc42, known to interact with Wiskott–Aldrich syndrome (WAS)
protein, is an important regulator of actin remodeling. Here, we show that genetic ablation of …

CD23 has been implicated as a negative regulator of IgE and IgG antibody responses.
However, whether CD23 has any role in B-cell activation remains unclear. We examined the …

Summary Humans with Wiskott-Aldrich syndrome display a progressive immunological
disorder associated with compromised Wiskott-Aldrich Syndrome Interacting Protein (WIP) …