Pharmacogenomics and COVID-19: clinical implications of human genome interactions with repurposed drugs

OA Badary - The pharmacogenomics journal, 2021 - nature.com
The outbreak of Coronavirus disease 2019 (COVID-19) has evolved into an emergent global
pandemic. Many drugs without established efficacy are being used to treat COVID-19 …

Bilirubin and endothelial function

T Maruhashi, Y Kihara, Y Higashi - Journal of atherosclerosis and …, 2019 - jstage.jst.go.jp
Bilirubin is an end product of heme degradation by heme oxygenases (HOs). At high
concentrations, bilirubin acts as a highly cytotoxic metabolite, which can cause brain …

Mechanisms in endocrinology: metabolic and body composition effects of newer antiretrovirals in HIV-infected patients

S Srinivasa, SK Grinspoon - European journal of endocrinology, 2014 - academic.oup.com
In the absence of a cure, HIV-infected patients are being successfully treated with
antiretroviral therapies (ART) and living longer. Indeed, an increasing number of HIV …

Exercise to prevent accelerated vascular aging in people living with HIV

R Jones, AT Robinson, LB Beach, ML Lindsey… - Circulation …, 2024 - Am Heart Assoc
Given advances in antiretroviral therapy, the mortality rate for HIV infection has dropped
considerably over recent decades. However, people living with HIV (PLWH) experience …

Stable patients and patients with advanced disease: consensus definitions to support sustained scale up of antiretroviral therapy

G Waldrop, M Doherty, M Vitoria… - Tropical Medicine & …, 2016 - Wiley Online Library
Objective As guidelines are evolving towards recommending starting antiretroviral therapy
(ART) in all HIV‐positive individuals irrespective of clinical and immunological status, HIV …

HIV protease inhibitor ritonavir impairs endothelial function via reduction in adipose mass and endothelial leptin receptor‐dependent increases in NADPH oxidase 1 …

T Bruder‐Nascimento, TC Kress… - Journal of the …, 2020 - Am Heart Assoc
Background Cardiovascular disease is currently the leading cause of death in patients with
human immunodeficiency virus on combination antiretroviral therapy. Although the use of …

HIV, combination antiretroviral therapy, and vascular diseases in men and women

L Kovacs, TC Kress, EJ Belin de Chantemèle - Basic to Translational …, 2022 - jacc.org
Thanks to the advent of combination antiretroviral therapy (cART), people living with human
immunodeficiency virus (HIV)(PLWH) experienced a marked increase in life expectancy but …

Arterial disease in patients with human immunodeficiency virus infection: what has imaging taught us?

JH Stein, JS Currier, PY Hsue - JACC: Cardiovascular Imaging, 2014 - jacc.org
With advances in antiretroviral therapy (ART), individuals with human immunodeficiency
virus (HIV) infection are living longer and increasingly die of non–HIV-related diseases, such …

HIV stroke risk: evidence and implications

EJ Singer, M Valdes-Sueiras… - … advances in chronic …, 2013 - journals.sagepub.com
An estimated 34 million men, women, and children are infected with human
immunodeficiency virus type 1 (HIV-1), the virus that causes acquired immunodeficiency …

Atazanavir/ritonavir-based combination antiretroviral therapy for treatment of HIV-1 infection in adults

CJ Achenbach, KM Darin, RL Murphy, C Katlama - Future virology, 2011 - Taylor & Francis
In the past 15 years, improvements in the management of HIV infection have dramatically
reduced morbidity and mortality. Similarly, rapid advances in antiretroviral medications have …