Circadian rhythm and sleep disruption: causes, metabolic consequences, and countermeasures
Abstract Circadian (∼ 24-hour) timing systems pervade all kingdoms of life and temporally
optimize behavior and physiology in humans. Relatively recent changes to our …
optimize behavior and physiology in humans. Relatively recent changes to our …
Development of the circadian system in early life: maternal and environmental factors
In humans, an adaptable internal biological system generates circadian rhythms that
maintain synchronicity of behavior and physiology with the changing demands of the 24-h …
maintain synchronicity of behavior and physiology with the changing demands of the 24-h …
Coffee, caffeine, and sleep: A systematic review of epidemiological studies and randomized controlled trials
I Clark, HP Landolt - Sleep medicine reviews, 2017 - Elsevier
Caffeine is the most widely consumed psychoactive substance in the world. It is readily
available in coffee and other foods and beverages, and is used to mitigate sleepiness …
available in coffee and other foods and beverages, and is used to mitigate sleepiness …
Pineal melatonin: cell biology of its synthesis and of its physiological interactions
RJ Reiter - Endocrine reviews, 1991 - academic.oup.com
I. Introduction U NTIL 35 yr ago, most scientists did not take research on the pineal gland
seriously. The decade beginning in 1956, however, provided several discoveries that laid …
seriously. The decade beginning in 1956, however, provided several discoveries that laid …
Melatonin in humans
A Brzezinski - New England journal of medicine, 1997 - Mass Medical Soc
Three centuries ago, the French philosopher René Descartes described the pineal gland as
“the seat of the soul,” but it was not until the late 1950s that melatonin, the principal …
“the seat of the soul,” but it was not until the late 1950s that melatonin, the principal …
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors
ML Dubocovich, P Delagrange, DN Krause… - Pharmacological …, 2010 - ASPET
The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in the
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …
pineal gland and retina, and in several peripheral tissues and organs. In the circulation, the …
Circadian system, sleep and endocrinology
CJ Morris, D Aeschbach, FAJL Scheer - Molecular and cellular …, 2012 - Elsevier
Levels of numerous hormones vary across the day and night. Such fluctuations are not only
attributable to changes in sleep/wakefulness and other behaviors but also to a circadian …
attributable to changes in sleep/wakefulness and other behaviors but also to a circadian …
The melatonin rhythm: both a clock and a calendar
RJ Reiter - Experientia, 1993 - Springer
The paper briefly reviews the data which shows that the circadian production and secretion
of melatonin by the pineal gland can impart both daily, ie, clock, and seasonal, ie, calendar …
of melatonin by the pineal gland can impart both daily, ie, clock, and seasonal, ie, calendar …
Functional MT1 and MT2 melatonin receptors in mammals
ML Dubocovich, M Markowska - Endocrine, 2005 - Springer
Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of
physiological processes in mammals. This review describes well-defined functional …
physiological processes in mammals. This review describes well-defined functional …
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
SM Reppert, DR Weaver, T Ebisawa - Neuron, 1994 - cell.com
The pineal hormone melatonin regulates seasonal reproductive function and modulates
circadian rhythms in mammals. We now report the cloning and characterization of a high …
circadian rhythms in mammals. We now report the cloning and characterization of a high …