This article summarizes anatomical, neurophysiological, pharmacological, and brain
imaging studies in humans and animals that have provided insights into the neural circuitry …

The afferent innervation of the urinary bladder consists primarily of small myelinated (Aδ)
and unmyelinated (C-fiber) axons that respond to chemical and mechanical stimuli …

BACKGROUND: Increased nerve growth factor (NGF) levels have been reported in the
bladder tissue and urine of patients with overactive bladder and detrusor overactivity (DO) …

Aims To summarize the changes that occur in the properties of bladder afferent neurons
following spinal cord injury. Methods Literature review of anatomical, immunohistochemical …

NGF has been suggested to play a role in urinary bladder dysfunction by mediating
inflammation, as well as morphological and functional changes, in sensory and sympathetic …

The lower urinary tract has two main functions, storage and periodic expulsion of urine, that
are regulated by a complex neural control system in the brain and lumbosacral spinal cord …

In the last two decades, nerve growth factor (NGF), initially described as a prototypical
trophic factor in the development of sensory and sympathetic innervation, has emerged as a …

Increased voiding frequency and urgency are among the most prevalent storage lower
urinary tract symptoms (LUTS), often diagnosed as part of overactive bladder syndrome …

Abstract Aims Neurotrophins (NTs) have attracted considerable attention in the urologic
community. The reason for this resides in the recognition of their ability to induce plastic …

Numerous neuropeptide/receptor systems including vasoactive intestinal polypeptide,
pituitary adenylate cyclase-activating polypeptide, calcitonin gene-related peptide …