Deciphering the multi-scale, quantitative cis-regulatory code
S Kim, J Wysocka - Molecular cell, 2023 - cell.com
Uncovering the cis-regulatory code that governs when and how much each gene is
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …
transcribed in a given genome and cellular state remains a central goal of biology. Here, we …
Advances in targeting 'undruggable'transcription factors with small molecules
MJ Henley, AN Koehler - Nature Reviews Drug Discovery, 2021 - nature.com
Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …
Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer
The switch/sucrose non-fermentable (SWI/SNF) complex has a crucial role in chromatin
remodelling and is altered in over 20% of cancers,. Here we developed a proteolysis …
remodelling and is altered in over 20% of cancers,. Here we developed a proteolysis …
Generating specificity in genome regulation through transcription factor sensitivity to chromatin
Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …
The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes
S Brahma, S Henikoff - Nature genetics, 2024 - nature.com
Chromatin accessibility is a hallmark of active transcription and entails ATP-dependent
nucleosome remodeling, which is carried out by complexes such as Brahma-associated …
nucleosome remodeling, which is carried out by complexes such as Brahma-associated …
The role and activity of SWI/SNF chromatin remodelers
T Bieluszewski, S Prakash, T Roulé… - Annual Review of Plant …, 2023 - annualreviews.org
SWITCH deficient SUCROSE NONFERMENTING (SWI/SNF) class chromatin remodeling
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …
complexes (CRCs) use the energy derived from ATP hydrolysis to facilitate access of …
Mammalian SWI/SNF continuously restores local accessibility to chromatin
M Iurlaro, MB Stadler, F Masoni, Z Jagani, GG Galli… - Nature …, 2021 - nature.com
Chromatin accessibility is a hallmark of regulatory regions, entails transcription factor (TF)
binding and requires nucleosomal reorganization. However, it remains unclear how …
binding and requires nucleosomal reorganization. However, it remains unclear how …
Profiling and functional characterization of maternal mRNA translation during mouse maternal-to-zygotic transition
Translational regulation plays an important role in gene expression and function. Although
the transcriptional dynamics of mouse preimplantation embryos have been well …
the transcriptional dynamics of mouse preimplantation embryos have been well …
Cooperation of chromatin remodeling SWI/SNF complex and pioneer factor AP-1 shapes 3D enhancer landscapes
The mechanism controlling the dynamic targeting of SWI/SNF has long been postulated to
be coordinated by transcription factors (TFs), yet demonstrating a specific TF influence has …
be coordinated by transcription factors (TFs), yet demonstrating a specific TF influence has …
Energy-driven genome regulation by ATP-dependent chromatin remodellers
The packaging of DNA into chromatin in eukaryotes regulates gene transcription, DNA
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …
replication and DNA repair. ATP-dependent chromatin remodelling enzymes (re) arrange …