[HTML][HTML] Clavulanic Acid Overproduction: A Review of Environmental Conditions, Metabolic Fluxes, and Strain Engineering in Streptomyces clavuligerus

D Gómez-Ríos, LM Gómez-Gaona, H Ramírez-Malule - Fermentation, 2024 - mdpi.com
Clavulanic acid is a potent β-lactamase inhibitor produced by Streptomyces clavuligerus,
widely used in combination with β-lactam antibiotics to combat antimicrobial resistance. This …

[HTML][HTML] Tuning of fed-batch cultivation of Streptomyces clavuligerus for enhanced Clavulanic Acid production based on genome-scale dynamic modeling

D Gómez-Ríos, H Ramírez-Malule, P Neubauer… - Biochemical …, 2022 - Elsevier
Streptomyces clavuligerus (S. clavuligerus) is a filamentous Gram-positive bacterial
producer of the β-lactamase inhibitor clavulanic acid (CA). Antibiotics biosynthesis and …

A combined sensitivity and metabolic flux analysis unravel the importance of amino acid feeding strategies in Clavulanic acid biosynthesis

C Sánchez, N Gómez, JC Quintero, S Ochoa… - … in Computational Biology …, 2014 - Springer
Metabolic flux analysis (MFA) is a computationally-dependent mathematical framework
which can be used for determining the more representative variables of a biological system; …

Dynamic in silico assessment of potential gene targets for enhancing clavulanic acid production in Streptomyces clavuligerus submerged cultures

D Gómez-Ríos, H Ramírez-Malule… - Journal of Applied …, 2023 - japsonline.com
Clavulanic acid (CA) is an antibiotic of the β-lactam class with moderate antimicrobial activity
but a high inhibitory effect on β-lactamase enzymes. CA is one of the most important …

Modeling of Clavulanic Acid Production from Streptomyces clavuligerus using a Continuous Operation Mode

L Ariza, J Rubio, V Moreno, L Niño… - Journal of Physics …, 2021 - iopscience.iop.org
Clavulanic acid is a β-lactam inhibitor produced by fermentation with Streptomyces
clavuligerus cells, and it is usually used to prevent resistance to certain antibiotics. However …

Alteraciones neuroconductuales en niños con autismo relacionadas con niveles de amonio plasmático y bacterias hidrolizantes de urea

XM Calderón, MF Garcés, B Rodríguez, C Hernández… - Revista GEN, 2022 - saber.ucv.ve
Introducción: Diversas teorías indican una relación estrecha entre la disbiosis intestinal y
sus metabolitos, en especial las que relacionan la presencia de amonio con alteraciones …

Obtención de poli-3-hibroxibutarato (p3hb) a partir de la Extracción de pectina del mucilago de café con streptomyces sp. Aislados de suelos de Boyacá (Colombia).

MP González Iguavita - intellectum.unisabana.edu.co
Los Polihidroxialcanoatos (PHA) son biopolímeros los cuales son producidos por distintas
especies bacterianas en condiciones de crecimiento de estrés, las cuales se encuentran …

Factores clínicos-epidemiológicos asociados a la multirresistencia en pacientes adultos con infección urinaria ingresados al Hospital de Ventanilla 2016

JE Pimentel Dionisio - 2018 - repositorio.urp.edu.pe
OBJETIVO: Determinar los factores clínicos-epidemiológicos asociados a la
multirresistencia en pacientes adultos con infección urinaria ingresados al Hospital de …

[PDF][PDF] EVALUATING ORNITHINE EFFECTS ON CLAVUNIC ACID BIOSYNTHESIS WITH THE AID OF METABOLIC FLUX ANALYSIS

C Sánchez, N Gómez, J Quintero, S Ochoa, R Rios - smbb.mx
“EVALUACIÓN DEL EFECTO DE MICROORGANISMOS EN TRATAMIENTOS Page 1 GAP
PEP PYR ACCOA TCA aKG OAA ORN ARG ASP GLU AC 195 100 X 75 113 183 -206 -1 18 …

Phenomenological Model of the Clavulanic Acid production, inhibitor of the enzymes β-lactamases using a method of multiple regression analysis nonlinear

NA Gómez, CP Sanchéz… - 2013 Pan American …, 2013 - ieeexplore.ieee.org
The filamentous bacterium Streptomyces clavuligerus (Sc), is of great commercial interest
and a metabolite of interest is Clavulanic Acid (CA), a potent inhibitor of the enzyme ß …