Transcriptional regulation by calcium, calcineurin, and NFAT
The NFAT family of transcription factors encompasses five proteins evolutionarily related to
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …
the Rel/NFκB family (Chytil and Verdine 1996; Graef et al. 2001b). The primordial family …
Cardiac hypertrophy: the good, the bad, and the ugly
N Frey, EN Olson - Annual review of physiology, 2003 - annualreviews.org
▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …
stimuli that impose increased biomechanical stress. While hypertrophy can eventually …
[HTML][HTML] Activation of cardiac fibroblast growth factor receptor 4 causes left ventricular hypertrophy
Chronic kidney disease (CKD) is a worldwide public health threat that increases risk of
death due to cardiovascular complications, including left ventricular hypertrophy (LVH) …
death due to cardiovascular complications, including left ventricular hypertrophy (LVH) …
[HTML][HTML] Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease
Patients with chronic kidney disease (CKD) develop increased levels of the phosphate-
regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk …
regulating hormone, fibroblast growth factor (FGF) 23, that are associated with a higher risk …
[HTML][HTML] NFAT signaling: choreographing the social lives of cells
GR Crabtree, EN Olson - Cell, 2002 - cell.com
Calcium signaling activates the phosphatase calcineurin and induces movement of NFATc
proteins into the nucleus, where they cooperate with other proteins to form complexes on …
proteins into the nucleus, where they cooperate with other proteins to form complexes on …
Hypertrophy of the heart: a new therapeutic target?
Recent studies call into question the necessity of hypertrophic growth of the heart as a
“compensatory” response to hemodynamic stress. These findings, coupled with recent …
“compensatory” response to hemodynamic stress. These findings, coupled with recent …
Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy
S Chen, CS Law, CL Grigsby, K Olsen, TT Hong… - Circulation, 2011 - Am Heart Assoc
Background—A variety of studies carried out using either human subjects or laboratory
animals suggest that vitamin D and its analogues possess important beneficial activity in the …
animals suggest that vitamin D and its analogues possess important beneficial activity in the …
[HTML][HTML] Regulation of fetal gene expression in heart failure
E Dirkx, PA da Costa Martins, LJ De Windt - Biochimica et Biophysica Acta …, 2013 - Elsevier
During the processes leading to adverse cardiac remodeling and heart failure,
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …
cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating …
Interaction of calcineurin with substrates and targeting proteins
H Li, A Rao, PG Hogan - Trends in cell biology, 2011 - cell.com
Calcineurin is a calcium activated protein phosphatase with a major role in calcium
signaling in diverse cells and organs and clinical importance as the target of the …
signaling in diverse cells and organs and clinical importance as the target of the …
Heart valve development: endothelial cell signaling and differentiation
EJ Armstrong, J Bischoff - Circulation research, 2004 - Am Heart Assoc
During the past decade, single gene disruption in mice and large-scale mutagenesis
screens in zebrafish have elucidated many fundamental genetic pathways that govern early …
screens in zebrafish have elucidated many fundamental genetic pathways that govern early …