Recently, there has been an increasing use of the cyclopropyl ring in drug development to
transition drug candidates from the preclinical to clinical stage. Important features of the …

The endothelium exerts multiple actions involving regulation of vascular permeability and
tone, coagulation and fibrinolysis, inflammatory and immunological reactions and cell …

Kinins are proinflammatory peptides that mediate numerous vascular and pain responses to
tissue injury. Two pharmacologically distinct kinin receptor subtypes have been identified …

Peripheral mediators can contribute to the development and maintenance of inflammatory
and neuropathic pain and its concomitants (hyperalgesia and allodynia) via two …

The kallikrein-kinin system is an endogenous metabolic cascade, triggering of which results
in the release of vasoactive kinins (bradykinin-related peptides). This complex system …

Kinins are among the most potent autacoids involved in inflammatory, vascular and pain
processes. These short-lived peptides, including bradykinin, kallidin and T-kinin, are …

G-protein-coupled receptors (GPCR) are involved in directly and indirectly controlling an
extraordinary variety of physiological functions. Their key roles in cellular communication …

Kinins, which are produced by the action of kallikrein enzymes, are blood-derived local-
acting peptides that have broad effects mediated by two related G-protein-coupled receptors …

Angioedema is an underestimated clinical problem. Many cases are nonallergic reactions,
eg bradykinin‐induced angioedema caused by genetic defects and angiotensin‐converting …

In 1949, Rocha e Silva and collaborators reported the existence of a new relaxing
substance, liberated in plasma by the action of the snake venom of Bothrops jararaca or by …