Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterised by
progressive muscular paralysis reflecting degeneration of motor neurones in the primary …

Motor neuron disease can be viewed as an umbrella term describing a heterogeneous
group of conditions, all of which are relentlessly progressive and ultimately fatal. The …

Familial amyotrophic lateral sclerosis (FALS) is an inherited neurodegenerative disorder of
the motor neurons. While 10–15% of cases are caused by mutations in the copper/zinc …

The mRNA transcript of the human STMN2 gene, encoding for stathmin-2 protein (also
called SCG10), is profoundly impacted by TAR DNA-binding protein 43 (TDP-43) loss of …

Objective To determine whether the GGC repeats in the NOTCH2NLC gene contribute to
amyotrophic lateral sclerosis (ALS). Methods In this study, 545 patients with ALS and 1,305 …

The dying forward hypothesis of motor neuron disease (MND) suggests that
corticomotoneurons induce excitotoxic anterior horn cell death, with involvement of the …

Objective To determine whether cortical hyperexcitability preceded the development of
lower motor neuron (LMN) dysfunction in sporadic amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) exhibits characteristic variability of onset and rate of
disease progression, with inherent clinical heterogeneity making disease quantitation …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by
progressive degeneration of upper and lower motoneurons, leading to muscle weakness …

Objective Cortical hyperexcitability has been established as an early feature of amyotrophic
lateral sclerosis (ALS). The evolution of cortical hyperexcitability with ALS progression …