The recent biotechnological progress has allowed life scientists and physicians to access an
unprecedented, massive amount of data at all levels (molecular, supramolecular, cellular …

In this chapter, we review Automated Tape Collecting Ultramicrotomy (ATUM), which, among
other array tomography methods, substantially simplified large-scale volume electron …

Synchrotron radiation microtomography (SRμCT) is a nominally non-destructive 3D imaging
technique which can visualise the internal structures of whole soft tissues. As a multi-stage …

In this work, we optimize the setups and experimental parameters of X-ray phase-contrast
computed-tomography for the three-dimensional imaging of the cyto-and myeloarchitecture …

Krabbe disease (KD) is a childhood leukodystrophy with no cure currently available. KD is
due to a deficiency of a lysosomal enzyme called galactosyl-ceramidase (GALC) and is …

Abstract Characterization of brain infarct lesions in rodent models of stroke is crucial to
assess stroke pathophysiology and therapy outcome. Until recently, the analysis of brain …

Purpose In the context of synchrotron microtomography using propagation-based phase-
contrast imaging (XSPCT), we evaluated the performance of semiautomatic and automatic …

The eukaryotic cell compartmentalizes into spatially confined, membrane-enclosed,
intracellular structures (eg, organelles, endosomes, and vesicles). Here, peculiar …

Three-dimensional biological microscopy presents a trade-off between spatial resolution
and field of view. Correlative approaches applying multiple imaging techniques to the same …

In the last decades, the advancements of microscopes technology, together with the
development of new imaging approaches, are trying to address some biological questions …