Non-coding RNAs and their integrated networks
Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are
different types of non-coding RNAs that modulate complex molecular and cellular …
different types of non-coding RNAs that modulate complex molecular and cellular …
Proteoglycan chemical diversity drives multifunctional cell regulation and therapeutics
The extracellular matrix (ECM) constitutes a highly dynamic three-dimensional structural
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
network comprised of macromolecules, such as proteoglycans/glycosaminoglycans …
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?
Here, we present a unifying hypothesis about how messenger RNAs, transcribed
pseudogenes, and long noncoding RNAs" talk" to each other using microRNA response …
pseudogenes, and long noncoding RNAs" talk" to each other using microRNA response …
ceRNA cross-talk in cancer: when ce-bling rivalries go awry
FA Karreth, PP Pandolfi - Cancer discovery, 2013 - AACR
The cancer transcriptome is characterized by aberrant expression of both protein-coding
and noncoding transcripts. Similar to mRNAs, a significant portion of the noncoding …
and noncoding transcripts. Similar to mRNAs, a significant portion of the noncoding …
A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
The canonical role of messenger RNA (mRNA) is to deliver protein-coding information to
sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized …
sites of protein synthesis. However, given that microRNAs bind to RNAs, we hypothesized …
The multilayered complexity of ceRNA crosstalk and competition
Y Tay, J Rinn, PP Pandolfi - Nature, 2014 - nature.com
Recent reports have described an intricate interplay among diverse RNA species, including
protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs …
protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs …
[HTML][HTML] Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
Here, we demonstrate that protein-coding RNA transcripts can crosstalk by competing for
common microRNAs, with microRNA response elements as the foundation of this …
common microRNAs, with microRNA response elements as the foundation of this …
Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis
W Yang, WW Du, X Li, AJ Yee, BB Yang - Oncogene, 2016 - nature.com
It has recently been shown that the upregulation of a pseudogene specific to a protein-
coding gene could function as a sponge to bind multiple potential targeting microRNAs …
coding gene could function as a sponge to bind multiple potential targeting microRNAs …
Tumor suppressor miR-34a targets PD-L1 and functions as a potential immunotherapeutic target in acute myeloid leukemia
XI Wang, J Li, KE Dong, F Lin, M Long, Y Ouyang… - Cellular signalling, 2015 - Elsevier
Abstract miRNA (miR) 34a has been shown to modulate critical gene transcripts involved in
tumorigenesis, but its role in tumor-mediated immunosuppression is largely unknown. PD …
tumorigenesis, but its role in tumor-mediated immunosuppression is largely unknown. PD …
Exosomes secreted by human cells transport largely mRNA fragments that are enriched in the 3′-untranslated regions
AO Batagov, IV Kurochkin - Biology direct, 2013 - Springer
Small secreted membrane vesicles called exosomes have recently attracted a great interest
after the discovery that they transfer mRNA that can be translated into protein in recipient …
after the discovery that they transfer mRNA that can be translated into protein in recipient …