The cell cycle is tightly regulated by cyclins and their catalytic moieties, the cyclin-dependent
kinases (CDKs). Cyclin D1, in association with CDK4/6, acts as a mitogenic sensor and …

Gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) are heterogeneous
regarding site of origin, biological behavior, and malignant potential. There has been a rapid …

The traditionally promulgated perspectives of neuroendocrine neoplasms (NEN) as rare,
indolent tumours are blunt and have been outdated for the last 2 decades. Clear increments …

Neuroendocrine tumours (NET) of the gastrointestinal tract and the lung are a rare and
heterogeneous group of tumours. The molecular characterization and the clinical …

Abstract Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs) arise throughout
the gut and feature varying biological behaviour and malignant potential. GEP-NENs include …

In addition to being a hallmark at active genes, histone variant H3. 3 is deposited by ATRX at
repressive chromatin regions, including the telomeres. It is unclear how H3. 3 promotes …

Gastrinomas are neuroendocrine neoplasms (NENs), that occur primarily in the duodenum
and pancreas, which ectopically secrete gastrin, resulting in the Zollinger-Ellison syndrome …

Neuroendocrine tumours (NETs) may arise throughout the body and are a highly
heterogeneous, relatively rare class of neoplasms difficult to study also for the lack of …

Pancreatic adenocarcinoma accounts for nearly 90–95% of exocrine malignant tumors of
the pancreas. Traditionally, overexpressed proteins/epitopes such as CA 19-9, CA-50, CEA …

Pancreatic neuroendocrine tumors (PanNENs) are rare sporadic cancers or develop as part
of hereditary syndromes. PanNENs can be both functioning and non-functioning based on …