Connecting omics signatures and revealing biological mechanisms with iLINCS
There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …
and interfaces for integrative analyses and visualization that do not require programming …
The sponge microbiome project
Rhododendron delavayi Franch. is globally famous as an ornamental plant. Its distribution in
southwest China covers several different habitats and environments. However, not much …
southwest China covers several different habitats and environments. However, not much …
Current advances in comprehensive omics data mining for oncology and cancer research
E Jeong, S Yoon - Biochimica et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
The availability of a large amount of multiomics data enables data-driven discovery studies
on cancers. High-throughput data on mutations, gene/protein expression, immune scores …
on cancers. High-throughput data on mutations, gene/protein expression, immune scores …
Derivation and application of molecular signatures to prostate cancer: opportunities and challenges
D Doultsinos, IG Mills - Cancers, 2021 - mdpi.com
Simple Summary Prostate cancer continues to exert a significant public health burden
across the globe with hundreds of thousands of new diagnoses per year. There have been …
across the globe with hundreds of thousands of new diagnoses per year. There have been …
Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal …
The Library of Integrated Network-based Cellular Signatures (LINCS) project is a large-scale
coordinated effort to build a comprehensive systems biology reference resource. The goals …
coordinated effort to build a comprehensive systems biology reference resource. The goals …
Interferon-complement loop in transplant-associated thrombotic microangiopathy
S Jodele, M Medvedovic, N Luebbering… - Blood …, 2020 - ashpublications.org
Transplant-associated thrombotic microangiopathy (TA-TMA) is an important cause of
morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The …
morbidity and mortality after hematopoietic stem cell transplantation (HSCT). The …
Connecting omics signatures of diseases, drugs, and mechanisms of actions with iLINCS
There are only a few platforms that integrate multiple omics data types, bioinformatics tools,
and interfaces for integrative analyses and visualization that do not require programming …
and interfaces for integrative analyses and visualization that do not require programming …
Inferring TF activities and activity regulators from gene expression data with constraints from TF perturbation data
CZ Ma, MR Brent - Bioinformatics, 2021 - academic.oup.com
Motivation The activity of a transcription factor (TF) in a sample of cells is the extent to which
it is exerting its regulatory potential. Many methods of inferring TF activity from gene …
it is exerting its regulatory potential. Many methods of inferring TF activity from gene …
An integrated multi-omics approach to identify regulatory mechanisms in cancer metastatic processes
Background Metastatic progress is the primary cause of death in most cancers, yet the
regulatory dynamics driving the cellular changes necessary for metastasis remain poorly …
regulatory dynamics driving the cellular changes necessary for metastasis remain poorly …
Integrating motif, DNA accessibility and gene expression data to build regulatory maps in an organism
C Blatti, M Kazemian, S Wolfe, M Brodsky… - Nucleic acids …, 2015 - academic.oup.com
Abstract Characterization of cell type specific regulatory networks and elements is a major
challenge in genomics, and emerging strategies frequently employ high-throughput genome …
challenge in genomics, and emerging strategies frequently employ high-throughput genome …