Possibilities and challenges for developing a successful vaccine for leishmaniasis

S Srivastava, P Shankar, J Mishra, S Singh - Parasites & vectors, 2016 - Springer
Leishmaniasis is a vector-borne disease caused by different species of protozoan parasites
of the genus Leishmania. It is a major health problem yet neglected tropical diseases, with …

Laboratory tests for diagnosing and monitoring canine leishmaniasis

S Paltrinieri, L Gradoni, X Roura… - Veterinary clinical …, 2016 - Wiley Online Library
Although several reviews on canine leishmaniasis have been published, none thoroughly
described clinicopathologic abnormalities and their clinical usefulness. The aim of this …

Pathologic Mechanisms Underlying the Clinical Findings in Canine Leishmaniosis due to Leishmaniainfantum/chagasi

AF Koutinas, CK Koutinas - Veterinary Pathology, 2014 - journals.sagepub.com
In dogs with symptomatic or asymptomatic leishmaniosis, Leishmania infantum appears to
induce a mixed Th1/Th2 immune response that in the sick dog may eventually result in …

Role of cytokines in experimental and human visceral leishmaniasis

M Samant, U Sahu, SC Pandey… - Frontiers in cellular and …, 2021 - frontiersin.org
Visceral Leishmaniasis (VL) is the most fatal form of disease leishmaniasis. To date, there
are no effective prophylactic measures and therapeutics available against VL. Recently, new …

Animal models for the study of leishmaniasis immunology

EN Loría-Cervera, FJ Andrade-Narváez - Revista do Instituto de …, 2014 - SciELO Brasil
Leishmaniasis remains a major public health problem worldwide and is classified as
Category I by the TDR/WHO, mainly due to the absence of control. Many experimental …

Biomarkers Associated With Leishmania infantum Exposure, Infection, and Disease in Dogs

C Maia, L Campino - Frontiers in cellular and infection microbiology, 2018 - frontiersin.org
Canine leishmaniosis (CanL) is a vector-borne disease caused by the protozoan
Leishmania (Leishmania) infantum species [syn. L.(L.) infantum chagasi species in the …

Insights on adaptive and innate immunity in canine leishmaniosis

S Hosein, DP Blake, L Solano-Gallego - Parasitology, 2017 - cambridge.org
Canine leishmaniosis (CanL) is caused by the parasite Leishmania infantum and is a
systemic disease, which can present with variable clinical signs, and clinicopathological …

Immunity to Leishmania and the rational search for vaccines against canine leishmaniasis

AB Reis, RC Giunchetti, E Carrillo, OA Martins-Filho… - Trends in …, 2010 - cell.com
The control of infection by Leishmania infantum (syn. Leishmania chagasi) in dogs is
essential to stop the current spread of zoonotic visceral leishmaniasis. The past few years …

Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog

C Maia, L Campino - Journal of Tropical Medicine, 2012 - Wiley Online Library
Leishmaniasis has reemerged in recent years showing a wider geographic distribution and
increased global incidence of human and canine disease than previously known. Dogs are …

Canine visceral leishmaniasis biomarkers and their employment in vaccines

RC Giunchetti, P Silveira, LA Resende, JC Leite… - Veterinary …, 2019 - Elsevier
The natural history of canine visceral leishmaniasis (CVL) has been well described,
particularly with respect to the parasite load in different tissues and immunopathological …