Significant research and preclinical investment in cancer nanomedicine has produced
several products, which have improved cancer care. Nevertheless, there exists a perception …

Cancer is a leading cause of death in many countries around the world. However, the
efficacy of current standard treatments for a variety of cancers is suboptimal. First, most …

Glioblastoma (GBM) is the most common primary malignant brain tumor in adults.
Regardless of ideal multidisciplinary treatment, including maximal surgical resection …

Doxil®, the first FDA-approved nano-drug (1995), is based on three unrelated principles:(i)
prolonged drug circulation time and avoidance of the RES due to the use of PEGylated nano …

Deregulated protein tyrosine kinase activity is central to the pathogenesis of human cancers.
Targeted therapy in the form of selective tyrosine kinase inhibitors (TKIs) has transformed …

Morpholine is a versatile moiety, a privileged pharmacophore and an outstanding
heterocyclic motif with wide ranges of pharmacological activities due to different …

Many tumor cells become resistant to commonly used cytotoxic drugs due to the
overexpression of ATP-binding cassette (ABC) transporters, namely P-glycoprotein (P-gp) …

Ovarian follicle pool depletion, infertility, and premature menopause are all known sequelae
of cancer treatment that negatively impact the quality of life of young cancer survivors. The …

Abstract Cytochrome 450 (CYP450) designates a group of enzymes abundant in smooth
endoplasmic reticulum of hepatocytes and epithelial cells of small intestines. The main …

Cancer cannot be controlled by the usage of drugs alone, and thus, nanotechnology is an
important technique that can provide the drug with an impetus to act more effectively. There …