Impact of obstructive sleep apnoea and intermittent hypoxia on cardiovascular and cerebrovascular regulation
AE Beaudin, X Waltz, PJ Hanly… - Experimental …, 2017 - Wiley Online Library
New Findings What is the topic of this review? This review examines the notion that
obstructive sleep apnoea (OSA) and intermittent hypoxia (IH) have hormetic effects on …
obstructive sleep apnoea (OSA) and intermittent hypoxia (IH) have hormetic effects on …
Apneic sleep, insufficient sleep, and hypertension
MP Mansukhani, N Covassin, VK Somers - Hypertension, 2019 - Am Heart Assoc
Animal studies have demonstrated an increase in BP with repeated upper airway closure
and intermittent hypoxia. 25–28 Studies of human subjects have demonstrated increased …
and intermittent hypoxia. 25–28 Studies of human subjects have demonstrated increased …
Acute intermittent hypercapnic hypoxia and sympathetic neurovascular transduction in men
TJR Stuckless, TD Vermeulen, CV Brown… - The Journal of …, 2020 - Wiley Online Library
Key points Intermittent hypoxia leads to long‐lasting increases in muscle sympathetic nerve
activity and blood pressure, contributing to increased risk for hypertension in obstructive …
activity and blood pressure, contributing to increased risk for hypertension in obstructive …
Peripheral chemoreflex contribution to ventilatory long‐term facilitation induced by acute intermittent hypercapnic hypoxia in males and females
TD Vermeulen, J Benbaruj, CV Brown… - The Journal of …, 2020 - Wiley Online Library
Key points Ventilatory long‐term facilitation (vLTF) refers to respiratory neuroplasticity that
develops following intermittent hypoxia in both healthy and clinical populations. A sustained …
develops following intermittent hypoxia in both healthy and clinical populations. A sustained …
[HTML][HTML] Intermittent hypoxia, cardiovascular disease and obstructive sleep apnoea
CD Turnbull - Journal of thoracic disease, 2018 - ncbi.nlm.nih.gov
Obstructive sleep apnoea (OSA) is a common disorder and is associated with
cardiovascular disease. Continuous positive airway pressure (CPAP), whilst reducing blood …
cardiovascular disease. Continuous positive airway pressure (CPAP), whilst reducing blood …
Experimental models to study end-organ morbidity in sleep apnea: lessons learned and future directions
R Farré, I Almendros, MÁ Martínez-García… - International Journal of …, 2022 - mdpi.com
Sleep apnea (SA) is a very prevalent sleep breathing disorder mainly characterized by
intermittent hypoxemia and sleep fragmentation, with ensuing systemic inflammation …
intermittent hypoxemia and sleep fragmentation, with ensuing systemic inflammation …
Sex differences in integrated neurocardiovascular control of blood pressure following acute intermittent hypercapnic hypoxia
DW Jacob, EP Ott, SE Baker… - American Journal …, 2020 - journals.physiology.org
Repetitive hypoxic apneas, similar to those observed in sleep apnea, result in resetting of
the sympathetic baroreflex to higher blood pressures (BP). This baroreflex resetting is …
the sympathetic baroreflex to higher blood pressures (BP). This baroreflex resetting is …
Circulating exosomes in obstructive sleep apnea as phenotypic biomarkers and mechanistic messengers of end-organ morbidity
A Khalyfa, L Kheirandish-Gozal, D Gozal - Respiratory physiology & …, 2018 - Elsevier
Obstructive sleep apnea (OSA), the most severe form of sleep disordered breathing, is
characterized by intermittent hypoxia during sleep (IH), sleep fragmentation, and episodic …
characterized by intermittent hypoxia during sleep (IH), sleep fragmentation, and episodic …
Oscillatory shear stress, flow-mediated dilatation, and circulating microparticles at sea level and high altitude
JC Tremblay, SR Thom, M Yang, PN Ainslie - Atherosclerosis, 2017 - Elsevier
Background and aims Exposing the endothelium to acute periods of imposed oscillatory
shear stress reduces endothelial function and elevates circulating microparticles (MPs) …
shear stress reduces endothelial function and elevates circulating microparticles (MPs) …
Acute hypoxia elicits lasting reductions in the sympathetic action potential transduction of arterial blood pressure in males
BM Shafer, M Nardone, AV Incognito… - The Journal of …, 2023 - Wiley Online Library
Post‐hypoxia sympathoexcitation does not elicit corresponding changes in vascular tone,
suggesting diminished sympathetic signalling. Blunted sympathetic transduction following …
suggesting diminished sympathetic signalling. Blunted sympathetic transduction following …