The main limitation to the success of central nervous system (CNS) therapies lies in the
difficulty for drugs to cross the blood–brain barrier (BBB) and reach the brain. Regarding its …

Colloidal systems based on lipids have attracted attention during the last two decades as a
delivery method of drugs that are poorly soluble in water. The investigations carried out have …

Lipid nanocarriers are developed as an alternative to polymeric nanoparticles, liposomes
and emulsions. Further, Nanostructured Lipid Nanocarriers are the second generation lipid …

This work briefly reviews up-to-date developments in solid lipid nanoparticles (SLNs) as
effective nanocolloidal system for drug delivery. It summarizes SLNs in terms of their …

Background Metastasis causes the most breast cancer-related deaths in women. Here, we
investigated the antitumor effect of solid lipid nanoparticles (SLN-DTX) when used in the …

Background In recent years, the field of nanotechnology and nanomedicine has transformed
the pharmaceutical industry with the development of novel drug delivery systems that …

Enteral administration is the most convenient route despite the gastrointestinal physiological
barriers. Nanostructured lipid carriers (NLCs) have emerged as a promising strategy for …

Although solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs) have
been successfully used as drug delivery systems for about 30 years, the usage of these …

Lipid-based drug delivery systems has become a popular choice for oral delivery of
lipophilic drugs with dissolution rate limited oral absorption. Lipids are known to enhance …

Oral delivery is the most accepted and economical route for drug administration and leads to
substantial reduction in dosing frequency. However, this route still remains a challenge for …