Owing to the efficacy in reducing pain and inflammation, non-steroidal anti-inflammatory
drugs (NSAIDs) are amongst the most popularly used medicines confirming their position in …

Cancer is a multifactorial, multi-stage disease, including complex cascades of signaling
pathways—the cell growth governed by dysregulated and abrupt cell division. Due to the …

A wide array of phenolic substances, particularly those present in edible and medicinal
plants, have been reported to possess substantial anticarcinogenic and antimutagenic …

Surrogate end-point biomarkers (SEBs) have become widely used in short-term cancer
chemoprevention trials in place of cancer end points. This paper discusses criteria relevant …

Numerous experimental, epidemiologic, and clinical studies suggest that nonsteroidal anti-
inflammatory drugs (NSAIDs), particularly the highly selective cyclooxygenase (COX)-2 …

Two cyclooxygenase isozymes catalyze conversion of arachidonic acid to prostaglandin H
2: constitutive COX-1 and inducible COX-2. To assess the role of COX-2 in colorectal …

BACKGROUND The cyclooxygenase (COX) enzyme catalyzes the formation of
prostaglandins, which can affect cell proliferation and alter the response of the immune …

Here we report the molecular identification of membrane-bound glutathione (GSH)-
dependent prostaglandin (PG) E 2 synthase (mPGES), a terminal enzyme of the …

Curcumin, derived from the rhizome of Curcuma longa L. and having both antioxidant and
anti-inflammatory properties, inhibits chemically induced carcinogenesis in the skin …

Abstract Cyclooxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin
biosynthesis and the target enzymes for the widely used nonsteroidal anti-inflammatory …