Recovery from disorders of consciousness: mechanisms, prognosis and emerging therapies

BL Edlow, J Claassen, ND Schiff… - Nature Reviews Neurology, 2021 - nature.com
Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …

Traumatic brain injury: an overview of epidemiology, pathophysiology, and medical management

A Capizzi, J Woo, M Verduzco-Gutierrez - Medical Clinics, 2020 - medical.theclinics.com
The goal of this article is to provide a general review of the epidemiology, acute care, and
chronic management of adult patients with traumatic brain injuries (TBI). This text was …

European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

D Kondziella, A Bender, K Diserens… - European journal of …, 2020 - Wiley Online Library
Background and purpose Patients with acquired brain injury and acute or prolonged
disorders of consciousness (DoC) are challenging. Evidence to support diagnostic decisions …

Practice guideline update recommendations summary: disorders of consciousness: report of the Guideline Development, Dissemination, and Implementation …

JT Giacino, DI Katz, ND Schiff, J Whyte, EJ Ashman… - Neurology, 2018 - AAN Enterprises
Objective To update the 1995 American Academy of Neurology (AAN) practice parameter on
persistent vegetative state and the 2002 case definition on minimally conscious state (MCS) …

Neural correlates of consciousness: progress and problems

C Koch, M Massimini, M Boly, G Tononi - Nature reviews neuroscience, 2016 - nature.com
There have been a number of advances in the search for the neural correlates of
consciousness—the minimum neural mechanisms sufficient for any one specific conscious …

Therapeutic interventions in patients with prolonged disorders of consciousness

A Thibaut, N Schiff, J Giacino, S Laureys… - The Lancet …, 2019 - thelancet.com
The management of patients with severe brain injuries and prolonged disorders of
consciousness raises important issues particularly with respect to their therapeutic options …

Consciousness is supported by near-critical slow cortical electrodynamics

D Toker, I Pappas, JD Lendner… - Proceedings of the …, 2022 - National Acad Sciences
Mounting evidence suggests that during conscious states, the electrodynamics of the cortex
are poised near a critical point or phase transition and that this near-critical behavior …

Robust EEG-based cross-site and cross-protocol classification of states of consciousness

DA Engemann, F Raimondo, JR King, B Rohaut… - Brain, 2018 - academic.oup.com
Determining the state of consciousness in patients with disorders of consciousness is a
challenging practical and theoretical problem. Recent findings suggest that multiple markers …

Signature of consciousness in the dynamics of resting-state brain activity

P Barttfeld, L Uhrig, JD Sitt, M Sigman… - Proceedings of the …, 2015 - National Acad Sciences
At rest, the brain is traversed by spontaneous functional connectivity patterns. Two
hypotheses have been proposed for their origins: they may reflect a continuous stream of …

Early detection of consciousness in patients with acute severe traumatic brain injury

BL Edlow, C Chatelle, CA Spencer, CJ Chu, YG Bodien… - Brain, 2017 - academic.oup.com
Abstract See Schiff (doi: 10.1093/awx209) for a scientific commentary on this article. Patients
with acute severe traumatic brain injury may recover consciousness before self-expression …