2024 heart disease and stroke statistics: a report of US and global data from the American Heart Association
BACKGROUND: The American Heart Association (AHA), in conjunction with the National
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …
Institutes of Health, annually reports the most up-to-date statistics related to heart disease …
Mendelian randomization for cardiovascular diseases: principles and applications
SC Larsson, AS Butterworth… - European heart journal, 2023 - academic.oup.com
Large-scale genome-wide association studies conducted over the last decade have
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …
uncovered numerous genetic variants associated with cardiometabolic traits and risk factors …
A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk
Despite intensive preventive cardiovascular disease (CVD) efforts, substantial residual CVD
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …
risk remains even for individuals receiving all guideline-recommended interventions. Niacin …
Pragmatic solutions to reduce the global burden of stroke: a World Stroke Organization–Lancet Neurology Commission
Executive summary Stroke is the second leading cause of death worldwide. The burden of
disability after a stroke is also large, and is increasing at a faster pace in low-income and …
disability after a stroke is also large, and is increasing at a faster pace in low-income and …
High‐Performance Hydrogel Sensors Enabled Multimodal and Accurate Human–Machine Interaction System for Active Rehabilitation
H Wang, Q Ding, Y Luo, Z Wu, J Yu, H Chen… - Advanced …, 2024 - Wiley Online Library
Human–machine interaction (HMI) technology shows an important application prospect in
rehabilitation medicine, but it is greatly limited by the unsatisfactory recognition accuracy …
rehabilitation medicine, but it is greatly limited by the unsatisfactory recognition accuracy …
The STROMICS genome study: deep whole-genome sequencing and analysis of 10K Chinese patients with ischemic stroke reveal complex genetic and phenotypic …
S Cheng, Z Xu, S Bian, X Chen, Y Shi, Y Li, Y Duan… - Cell Discovery, 2023 - nature.com
Ischemic stroke is a leading cause of global mortality and long-term disability. However,
there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in …
there is a paucity of whole-genome sequencing studies on ischemic stroke, resulting in …
The predominant PAR4 variant in individuals of African ancestry worsens murine and human stroke outcomes
F Denorme, ND Armstrong, ML Stoller… - The Journal of …, 2023 - Am Soc Clin Investig
Protease-activated receptor 4 (PAR4)(gene F2RL3) harbors a functional dimorphism,
rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet …
rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet …
Identification of novel protein biomarkers and drug targets for colorectal cancer by integrating human plasma proteome with genome
J Sun, J Zhao, F Jiang, L Wang, Q Xiao, F Han… - Genome medicine, 2023 - Springer
Background The proteome is a major source of therapeutic targets. We conducted a
proteome-wide Mendelian randomization (MR) study to identify candidate protein markers …
proteome-wide Mendelian randomization (MR) study to identify candidate protein markers …
Genetic evidence for causal association between atrial fibrillation and dementia: a Mendelian randomization study
M Li, C Jiang, Y Lai, Y Wang, M Zhao, S Li… - Journal of the …, 2023 - Am Heart Assoc
Background The knowledge gap regarding whether the correlation between atrial fibrillation
(AF) and dementia in observational studies is causation or driven by other shared risk …
(AF) and dementia in observational studies is causation or driven by other shared risk …
Reversal agents for current and forthcoming direct oral anticoagulants
Over the past 20 years, there has been a shift from vitamin K antagonists to direct oral
anticoagulants (DOACs), which include the thrombin inhibitor dabigatran and the factor Xa …
anticoagulants (DOACs), which include the thrombin inhibitor dabigatran and the factor Xa …