The steadfast advance of the synthetic biology field has enabled scientists to use genetically
engineered cells, instead of small molecules or biologics, as the basis for the development …

Receptors enable cells to detect, process and respond to information about their
environments. Over the past two decades, synthetic biologists have repurposed physical …

Many cancers carry recurrent, change-of-function mutations affecting RNA splicing factors.
Here, we describe a method to harness this abnormal splicing activity to drive splicing factor …

A fundamental challenge in synthetic biology is to create molecular circuits that can program
complex cellular functions. Because proteins can bind, cleave, and chemically modify one …

Many biological circuits comprise sets of protein variants that interact with one another in a
many-to-many, or promiscuous, fashion. These architectures can provide powerful …

Cell and gene therapies hold tremendous promise for treating a range of difficult-to-treat
diseases. However, concerns over the safety and efficacy require to be further addressed in …

The ability to integrate biological signals and execute a functional response when
appropriate is critical for sophisticated cell engineering using synthetic biology. Although the …

Regulated proteolysis is a pivotal regulatory mechanism in all living organisms from bacteria
to mammalian cells and viruses. The ability to design proteases to sense, transmit, or trigger …

The widespread application of CRISPR‐Cas9 has transformed genome engineering.
Nevertheless, the precision to control the targeting activity of Cas9 requires further …

Proteases function as pivotal molecular switches, initiating numerous biological events.
Notably, potyviral protease, derived from plant viruses, has emerged as a trusted proteolytic …