Liver organ-on-chip models for toxicity studies and risk assessment

T Messelmani, L Morisseau, Y Sakai, C Legallais… - Lab on a Chip, 2022 - pubs.rsc.org
The liver is a key organ that plays a pivotal role in metabolism and ensures a variety of
functions in the body, including homeostasis, synthesis of essential components, nutrient …

[HTML][HTML] Microfluidic organ-on-a-chip devices for liver disease modeling in vitro

P Kanabekova, A Kadyrova, G Kulsharova - Micromachines, 2022 - mdpi.com
Mortality from liver disease conditions continues to be very high. As liver diseases manifest
and progress silently, prompt measures after diagnosis are essential in the treatment of …

[HTML][HTML] Cancer-on-chip: a 3D model for the study of the tumor microenvironment

E Cauli, MA Polidoro, S Marzorati, C Bernardi… - Journal of Biological …, 2023 - Springer
The approval of anticancer therapeutic strategies is still slowed down by the lack of models
able to faithfully reproduce in vivo cancer physiology. On one hand, the conventional in vitro …

[HTML][HTML] Liver spheroids on chips as emerging platforms for drug screening

D Huang, X Zhang, X Fu, Y Zu, W Sun, Y Zhao - Engineered Regeneration, 2021 - Elsevier
Liver plays a critical role in drug metabolism and nowadays multi-cellular culture systems
aiming at imitating liver-specific morphology and functionality are advancing robustly …

[HTML][HTML] Design, simulation, and evaluation of polymer-based microfluidic devices via computational fluid dynamics and cell culture “on-chip”

N Bakuova, S Toktarkan, D Dyussembinov, D Azhibek… - Biosensors, 2023 - mdpi.com
Organ-on-a-chip (OoC) technology has experienced exponential growth driven by the need
for a better understanding of in-organ processes and the development of novel approaches …

An Insight on Microfluidic Organ-on-a-Chip Models for PM2.5-Induced Pulmonary Complications

D Shah, B Dave, MR Chorawala, BG Prajapati… - ACS …, 2024 - ACS Publications
Pulmonary diseases like asthma, chronic obstructive pulmonary disorder, lung fibrosis, and
lung cancer pose a significant burden to global human health. Many of these complications …

[HTML][HTML] Validation of HepG2/C3A cell cultures in cyclic olefin copolymer based microfluidic bioreactors

L Etxeberria, T Messelmani, JH Badiola, A Llobera… - Polymers, 2022 - mdpi.com
Organ-on-chip (OoC) technology is one of the most promising in vitro tools to replace the
traditional animal experiment-based paradigms of risk assessment. However, the use of …

[HTML][HTML] Construction of in vitro liver-on-a-chip models and application progress

J Liu, Y Du, X Xiao, D Tan, Y He, L Qin - BioMedical Engineering OnLine, 2024 - Springer
The liver is the largest internal organ of the human body. It has a complex structure and
function and plays a vital role in drug metabolism. In recent decades, extensive research has …

Cyclic olefin copolymers (COC)—excellent glass formers with low dynamic fragility

R Zhang, V Madhavi, TD Shaffer… - Macromolecular …, 2022 - Wiley Online Library
Applications of cyclic olefin copolymers (COC) are manifold, and developing a complete
understanding of the characteristics of the glass transition behavior of these materials is …

Evaluation of membranes for mimicry of an alveolar-capillary barrier in microfluidic lung-on-a-chip devices

A Kadyrova, P Kanabekova, A Martin… - Materials Today …, 2022 - Elsevier
An alveolar basement membrane plays a crucial role in the organogenesis and functioning
of the lungs at the alveoli level. To emulate the function of the basement membrane in …